PURPOSE The authors examined the development of lateral interactions between neurons in the human visual system through the use of visual evoked potentials (VEPs) elicited by windmill-dartboard stimuli. Previously, these VEPs have revealed two distinct types of lateral interactions (short-range and long-range) in adults. This study aims to track the development of these interactions in the firs...

We present a novel Fourier domain method for microscopic imaging – so-called kmicroscopy– with lateral resolution independent of the detection numerical aperture. The concept is based on sample illumination by a lateral fringe-pattern of varying spatial frequency, which probes the lateral spatial frequency or kspectrum of the sample structure. The illumination pattern is realized by interferenc...

It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations, while their primary afferent inputs, neurons in the lateral geniculate nucleus (LGN), respond well to all orientations. Mechanisms based on intracortical inhibition and/or converging thalamocortical afferents have previously been suggested to underlie the generation of cortical orientat...

Cognitively demanding tasks require neurons of the prefrontal cortex (PFC) to encode divergent behaviorally relevant information. In discrimination tasks with arbitrary and learned categories, context-specific parameters shape and adapt the tuning functions of PFC neurons. We explored if and how selectivity of PFC neurons to visual numerosities, a 'natural' abstract category, may change dependi...

Expertise can increase working memory (WM) performance, but the cognitive and neural mechanisms of these improvements remain unclear. Here, we used functional magnetic resonance imaging to assess the degree to which expertise acquisition is supported by tuning of occipitotemporal object representations and tuning of prefrontal and parietal networks that may support domain-specific WM skills. We...

It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations while their primary a erent inputs neurons in the lateral geniculate nucleus LGN respond well to all orientations Mechanisms based on intracortical inhibition and or converging thalamocortical a erents have previ ously been suggested to underlie the generation of cortical orientation sel...

We present a quantitative analysis of the visual response properties of single neurons in the dorsal lateral geniculate nucleus (dLGN) of wild-type C57Bl/6J mice. Extracellular recordings were made from single dLGN cells in mice under halothane and nitrous oxide anaesthesia. After mapping the receptive fields (RFs) of these cells using reverse correlation of responses to flashed square stimuli,...

We used source imaging of visual evoked potentials to measure neural population responses over a wide range of horizontal disparities (0.5-64 arcmin). The stimulus was a central disk that moved back and forth across the fixation plane at 2 Hz, surrounded either by binocularly uncorrelated dots (disparity noise) or by correlated dots presented in the fixation plane. Both disk and surround were c...

The rat is a widely used species for study of the auditory system. Psychophysical results from rats have shown an inability to discriminate sound source locations within a lateral hemifield, despite showing fairly sharp near-midline acuity. We tested the hypothesis that those characteristics of the rat's sound localization psychophysics are evident in the characteristics of spatial sensitivity ...