Psoriasis is an inflammatory disorder which leads to the improper stratification of epidermal keratinocytes. Autophagic flux analysis our established cell lines has shown that autophagy functionally active in healthy keratinocytes but impaired psoriatic To mirror psoriasis vitro we custom-made a cytokine cocktail induced IL-1β release keratinocyte cultures. Stimulation by this chronic similarly...

Engineered Cementitious Composites (ECC) is an emerging cementitious composite material with ultra-high ductility. However, its higher cement dosage limits greenness and leads to concerns drying shrinkage. In this research, ECC utilizing limestone calcined clay (LC3) calcium sulphoaluminate (CSA) investigated, focusing on minimizing the material's embodied carbon while enhancing durability intr...

Ordinary Portland Cement (OPC) is by mass the largest manufactured product on Earth, responsible for approximately 6% - 8% of global anthropogenic carbon dioxide emissions (CO2) and 35% industrial CO2 emissions. On average 0.8 to 0.9 ton emitted produce one OPC. In this paper, partial substitution clinker (30% 35%) calcined clay-limestone mixture was investigated in order an eco-cement (LC3). A...

One of the major durability concerns for limestone calcined clay cement (LC3) concrete is its high susceptibility to atmospheric carbonation that could lead an early onset electrochemical corrosion reinforcing steel in structures. Aimed at designing innovative LC3 formulations with potentially enhanced resistance, this preliminary study investigates influence reactive magnesia (MgO) on early-ag...

Autofagi merupakan proses adaptasi yang dilakukan sebagai pertahanan dalam respon seluler, seperti kekurangan nutrisi atau stress metabolik lain. Mekanisme autofagi diregulasi oleh protein dinamakan Autophagy-Related Genes (ATG). juga telah banyak dikaitkan dengan berbagai penyakit pada manusia, misalnya kanker degeneratif lainnya. Ricin toksik berasal dari biji jarak Ricinus communis L. dan di...

Selective autophagy can be mediated via receptor molecules that link specific cargoes to the autophagosomal membranes decorated by ubiquitin-like microtubule-associated protein light chain 3 (LC3) modifiers. Although several autophagy receptors have been identified, little is known about mechanisms controlling their functions in vivo. In this work, we found that phosphorylation of an autophagy ...

Autophagy is a catabolic process by which cells degrade their own cytoplasmic constituents. Cells respond to the stress response of nutrient deficiency by degrading a portion of their cellular components to produce amino acids and energy. Recently, it became evident that the autophagic machinery is also involved in a kind of innate immune system. Some bacteria that invade mammalian cells are ev...