Acetaminophen (APAP) intoxication is a common cause of hepatic toxicity and life-threatening hepatic failure. However, few studies have investigated the possible association between APAP intoxication and acute kidney injury (AKI). We constructed a retrospective cohort study to clarify the relationship between APAP intoxication and the risk of AKI.We identified patients with APAP intoxication an...

Organophosphate (OP) poisoning is one of the most common toxicological emergencies, especially in developing countries. They work by inhibiting cholinesterase enzyme lead to severe cholinergic toxicities. Organophosphorus intoxication occurs after cutaneous exposure, respiratory inhalation or gastrointestinal tract absorption. Exposure to organophosphate and other agents increases yearly, with ...

A case of acute renal failure is reported in a patient with severe lithium intoxication. Renal biopsy showed damage in the proximal tubules with less marked changes in the glomeruli and interlobular arteries. Lithium was withdrawn, and after treatment with peritoneal dialysis the patient regained normal renal function. "' The accumulation of lithium is known to lead to acute renal failure in th...

introduction vit d level is low in human milk (20-60 iu/lit) thus dialy supplement of 400 vit d is advised since birth for all infants. on the other hand upper limit dose for long term vit d intake is 1000 iu/day for children less than one year of age. excessive vit d more than upper limit by physicians or parents can cause hypervitaminosed. we report a rare case of hypervitaminose d in two mon...

In this article, we check and develop further some postulates of the theory and mathematical modeling of combined toxic effect that we proposed earlier [1]. To this end, we have analyzed the results of an experiment on rats exposed during 6 weeks to repeated intraperitoneal injections of lead acetate, sodium fluoride or both. The development of intoxication was estimated quantitatively with 54 ...

Similarities between lead-induced anemia and a new hereditary erythorenzymopathy involving pyrimidine-specific 5'-nucleotidase prompted studies of the effects of lead on this and other erythrocyte enzymes. In vitro incubations of normal mature erythrocytes demonstrated that significant inhibition of pyrimidine 5'-nucleotidase occurred in the presence of lead at concentrations that had minimal e...