We consider the following Minimum Connectivity Inference problem (MCI), which arises in structural biology: given vertex sets Vi ⊆ V, i ∈ I, nd the graph G = (V,E) minimizing the size of the edge set E, such that the sub-graph of G induced by each Vi is connected. This problem arises in structural biology, when one aims at nding the pairwise contacts between the proteins of a protein assembly, ...

Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS; UMR 5235, case 107, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. Institut de Biologie et Chimie des Protéines (IBCP UMR 5086), CNRS, Université Lyon1, IFR128 BioSciences, Lyon-Gerland, 7 passage du Vercors, 69367 Lyon Cedex 07, France. Institut National de l...

Chemistry Aware Model Builder Isidro Cortes-Ciriano∗1,5, Daniel S. Murrell†2,5, Gerard J. P. van Westen, Ian P. Stott, Andreas Bender, Therese E. Malliavin, and Robert C. Glen Unite de Bioinformatique Structurale, Institut Pasteur and CNRS UMR 3825, Structural Biology and Chemistry Department, 25-28, rue Dr. Roux, 75 724 Paris, France. Unilever Centre for Molecular Science Informatics, Departme...

We give a demonstration of an application of XRCE's controlled text authoring system MDA to biological experiment reports. This work is the result of a collaboration between XRCE's Document Content Models team, CNRS's Institut de Biologic Structurale, and Protein'eXpert, a company specialized in biotechnology based in Grenoble. We start with a brief presentation of the partners involved and the...

Daniel S. Murrell∗1,5, Isidro Cortes-Ciriano†2,5, Gerard J. P. van Westen, Ian P. Stott, Andreas Bender, Therese E. Malliavin, and Robert C. Glen Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom. Unite de Bioinformatique Structurale, Institut Pasteur and CNRS UMR 3825, Structural Biology and Chemistry Department, 25-2...

a Facultés Universitaires Notre-Dame de la Paix, Laboratoire de Chimie Moléculaire Structurale, 61 rue de Bruxelles, 5000 Namur, Belgium. E-mail: [email protected] b Biocis (URA-CNRS 1843), Faculté de Pharmacie, 5 rue JB-Clément, 92296 Châtenay-Malabry, Cedex, France c Laboratoire des Sciences Moléculaires, Institut de Chimie de La Matière Condensée de Bordeaux, Avenue du Dr Schweltzer...

Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694 Emmanuelle Laffly, Ludivine Danjou, Florence Condemine, Dominique Vidal, Emmanuel Drouet, Marie-Paule Lefranc, Chantal Bottex, and Philippe Thullier* EA 2939 GDR CNRS, Virol...

From the Laboratoire des Protéines du Cytosquelette and Laboratoire de Moteurs Moléculaires, Institut de Biologie Structurale (Commissariat à l’Energie Atomique-CNRS-UJF), 41 Rue Jules Horowitz, 38027 Grenoble Cedex 01, France, Laboratoire du Cytosquelette, INSERM Unite 366, Commissariat à l’Energie Atomique, 38054 Grenoble Cedex 9, France, Laboratoire de Chimie Organique Appliquée, Institut Gi...

John W. Wright, Elizabeth Tamura-Myers, Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, and Joseph W. Harding Departments of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Program in Neuroscience, Washington State University, Pullman, WA 99164-4820, Institut National de la Santé et de la Recherche Medicale, Unite 266, Department de P...

Institut de Biologie Structurale Jean-Pierre Ebel, CEA-CNRS, of PL in solution. The PL–CL structure (van Tilbeurgh 41 Avenue des Martyrs, 38027 Grenoble Cedex 1, 2Large Scale et al., 1993), in turn, shows that the active site is exposed Structures Group, Institut Laue-Langevin, BP 156, 38042 Grenoble and the flap makes a series of polar contacts with CL. and 3Laboratoire de Bioénergétique et d’...