Objective: It has been well documented that oxidative stress is involved in the pathogenesis of cardiac diseases. Previous studies have shown that pomegranate seed oil (PSO) has antioxidant properties. This study was designed to investigate probable protective effects of PSO against hydrogen peroxide (H2O2)-induced damage in H9c2 cardiomyocytes.Materials and Methods: The cells were pretreated 2...

Introduction: Busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. The aim of this study was to assess antioxidant status, reactive oxygen species (ROS) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. Materials and Methods: Forty adult NMRI mice (30 ± 5 g) were divided...

The present investigation is aimed to carry out the in vitro lipid peroxidation and antimicrobial activities of the methanol extract of Mucuna pruriens (MEMP) (Family: Fabaceae) seeds. Lipid peroxidation was monitored by the change in optical density of the prepared concentrations (10-320 g/ml) and the % inhi-bition was calculated. Ascorbate/FeSO4-induced peroxidation was inhibited by standard ...

Objective(s): Rutin is a flavonoid with potent antioxidant property, which exhibited cytoprotective effects in several models of neuronal injury. This work aimed to examine whether rutin can protect neurons against oxidative DNA damage caused by serum/glucose deprivation (SGD) as an in vitro model of neurodegeneration and ischemia. Materials and Metho...

Ferritin and haemosiderin were shown, by the measurement of malondialdehyde production and loss of polyunsaturated fatty acids, to stimulate lipid peroxidation in liposomes. At pH 7.4 ascorbate was additionally required to achieve peroxidation; however, peroxidation occurred at pH 4.5 in the presence of iron-proteins alone. The damage was completely inhibited by the incorporation of chain-break...

Effect of flaxseeds supplementation on serum lipid profile of selected hypercholesteremic patients was studied. Flaxseeds were processed (roasted) and analysed for its nutritional and fatty acid profile and incorporated into chapattis (15gms) and evaluated organoleptically. Administration of roasted Flaxseed powder of 15 gm for 4 weeks produces significant (P<0.001) reduction of serum total cho...

Objective: The aim of this study was to design and optimize lipid based beads for multiunit floating drug delivery ramipril.&#x0D; Methods: prepared by melt-solidification method. In the investigation 32 full factorial used investigate joint influence two formulation variable amount Gelucire (X1) Tween 20 (X2) as independent percentage release in 1 (Y1), 6 (Y2), 12 h (Y3) dependent variable. 43...

Purpose of the study. The goal present study was to evaluate effect low dosed statins (rosuvastatin 10 mg/day) on state lipid and carbohydrate metabolism, insulin levels, vascular endothelial function, markers systemic inflammation in patients with ischemic heart disease combination diabetes mellitus.&#x0D; Materials research methods. We examined 83 type 2 mellitus aged 44 78 years (mean age (5...

OBJECTIVE To report a case of rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. CASE SUMMARY A 55-year-old man was taking an extract of C. mukul 300 mg 3 times daily to lower his cholesterol level. He developed rhabdomyolysis with hemoglobinuria after 2 weeks of treatment. Laboratory tests showed creatine kinase 144600 IU/L (reference range 24-195), myoglobin >3000 ng...