نتایج جستجو برای: locomotor deficits
تعداد نتایج: 65456 فیلتر نتایج به سال:
objective(s): scutellarin, a flavonoid extracted from the medicinal herb erigeron breviscapus hand-mazz, protects neurons from damage and inhibits glial activation. here we examined whether scutellarin may also protect neurons from hypoxia-induced damage. materials and methods: mice were exposed to hypoxia for 7 days and then administered scutellarin (50 mg/kg/d) or vehicle for 30 days cognitiv...
Introduction: Aging is the major risk factor for neurodegenerative diseases and oxidative stress is involved in the pathophysiology of these diseases. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. Methods: In this study, we investigated the possible antioxidant and neuroprotective properties o...
Cognitive dysfunctions are the main symptoms associated with Alzheimer's disease (AD). In last decade, use of natural substances to prevent or alleviate neurological have attracted great interest. Curcumin, polyphenolic component turmeric ( Curcuma longa ) rhizomes, has a variety beneficial properties, including potent antioxidant and anti-inflammatory properties. Despite therapeutic potential ...
BACKGROUND Locomotor adaptability is based on the implementation of error-feedback information from previous perturbations to predictively adapt to expected perturbations (feedforward) and to facilitate reactive responses in recurring unexpected perturbations ('savings'). The effect of aging on predictive and reactive adaptability is yet unclear. However, such understanding is fundamental for t...
Insulin-like growth factor 2 (IGF2) as a microglia-derived anti-inflammatory cytokine has a pivotal activity in memory consolidation. However, there is limited evidence on brain cell-originated IGF2 expression, regulation and function in pathological condition and neuro-inflammation. Hence, the present study was conducted to investigate the effect of IGF2 on improving the memory impairment in a...
Multiple Sclerosis (MS) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. The temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. Myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...
The effects of serotoninergic and noradrenergic drugs (applied intrathecally) on treadmill locomotion were evaluated in two adult cats subjected to a ventral and ventrolateral spinal lesion (T13). Despite the extensive spinal lesion, severely damaging important descending pathways such as the reticulo- and vestibulospinal tracts, both cats recovered quadrupedal voluntary locomotion. As detailed...
The role of histamine H3 receptors (H3Rs) in memory and the prospective H3R antagonists pharmacological control neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, procognitive effects acute systemic administration antagonist E169 (2.5–10 mg/kg, i.p.) on MK801-induced amnesia C57BL/6J mice using novel object recognition test (NORT) were evaluated. (5 mg) pr...
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