نتایج جستجو برای: low dose pre
تعداد نتایج: 1712576 فیلتر نتایج به سال:
Background & objectives: Cardiopulmonary bypass often causes a stress hormonal response with subsequent changes in hemodynamic and organ perfusion. Human studies involving cardiopulmonary bypass have shown that very low doses of ketamine can attenuate inflammatory and stress markers, without adverse effects. The aim of this study was to investigate whether low dose infusion of ketamine have hem...
Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo
5-fluorouracil (5FU) is an effective anti-cancer drug, yet its mechanism of action remains unclear. Here, we examine the effect of 5FU on pre-mRNA splicing in vivo. Using RT-PCR, we show that the splicing of a number of pre-mRNAs is inhibited in HeLa cells that have been exposed to a low dose of 5FU. It appears that this inhibitory effect is not due to its incorporation into pre-mRNA, because p...
Presynaptic imidazoline receptors (R(i-pre)) are found in the sympathetic axon terminals of animal and human cardiovascular systems, and they regulate blood pressure by modulating the release of peripheral noradrenaline (NA). The cellular mechanism of R(i-pre)-induced inhibition of NA release is unknown. We, therefore, investigated the effect of R(i-pre) activation on voltage-dependent Ca(2+) c...
Background For radiological protection and control, the International Commission on Radiological Protection (ICRP) provides nominal risk coefficients related to radiation exposure, which can be extrapolated using excess relative absolute obtained from Life Span Study of atomic bomb survivors in Hiroshima Nagasaki with dose dose-rate effectiveness factor (DDREF). Materials Methods Since it is im...
Whole-gland low-dose rate (LDR) brachytherapy has been a well-established modality of treating low-risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs. Focal treatment using LDR brachytherapy has been relatively unexplored, but it may offer advantages over other modalities that have established experiences with a focal approach. This is...
We thank Brasky et al. for their review (Brasky et al., 2016) of our meta-analysis on the association between NSAID use and risk of endometrial cancer (Verdoodt et al., 2016). We welcome the additional information on two of their studies, and the discussion points they have raised, which are valuable contributions to the topics discussed in our meta-analysis. Below we respond to the issues rais...
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