We used the secretion of the novel salmon cardiac peptide (sCP) as a model to examine the mechanisms of ventricular hormone release. Mechanical load increased dose dependently the secretion of immunoreactive sCP from isolated perfused salmon ventricle, with 3. 3-fold increase when a load of 13 cmH(2)O was applied. Endothelin-1 (5 nmol/l) was also able to rapidly increase the secretion of sCP. T...

INTRODUCTION Although fatigue has been implicated in cartilage failure, there are only two published studies in this area, by the same author. However, in these previous studies cartilage was tested in the direction parallel to that of collagen orientation in the superficial layer, where it possesses greater tensile strength. In the present work, articular cartilage was also tested along the di...

OBJECTIVE To present a form of therapeutic mechanical load, Graston Technique (GT)-an instrument-assisted soft tissue mobilization method) in three case studies including supraspinatus tendinosis, Achilles tendinosis, and plantar fasciosis. METHOD In each case study, case history and functional testing confirmed the presence of a condition characterized by degenerated soft tissue. Each condit...

Hypertrophic scars occur following cutaneous wounding and result in severe functional and esthetic defects. The pathophysiology of this process remains unknown. Here, we demonstrate for the first time that mechanical stress applied to a healing wound is sufficient to produce hypertrophic scars in mice. The resulting scars are histopathologically identical to human hypertrophic scars and persist...

Porous materials are lightweight, flexible and resistant to hairline cracks, so today with the development of technology porous structure produced for use in various industries. This structure widely use in beams, plates and shells. The purpose of this paper is to investigate the effect of porosity in axial symmetry in bending and buckling load sheet for analysis. For this purpose, a circular p...

In this study, for predicting arterial function and pathogenesis from a mechanical viewpoint, we develop a continuum mechanical model of an arterial wall that embodies residual and active stresses following a traditional anisotropic passive constitutive law. The residual and active stresses are incorporated into finite element methods based on a two-field variational principle described in the ...

Many load bearing biological structures (LBBSs)-such as feather rachises and spicules-are small (<1 mm) but not microscopic. Measuring the flexural behavior of these LBBSs is important for understanding the origins of their remarkable mechanical functions. We describe a protocol for performing three-point bending tests using a custom-built mechanical testing device that can measure forces rangi...

The complex structure of tendons relates to their mechanical properties. Previous research has associated the waviness of collagen fibers (crimp) during quasi-static tensile loading to tensile mechanical properties, but less is known about the role of fatigue loading on crimp properties. In this study (IACUC approved), mouse patellar tendons were fatigue loaded while an integrated plane polaris...