This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

this paper investigates the problem of selecting and scheduling a set of projects among available projects. each project consists of several tasks and to perform each one some resource is required. the objective is to maximize total benefit. the paper constructs a mathematical formulation in form of mixed integer linear programming model. three effective metaheuristics in form of the imperialis...

A stabilised low-order finite element methodology is presented for the numerical simulation of a mixed conservation law formulation in fast solid dynamics. The mixed formulation, where the unknowns are linear momentum, deformation gradient and total energy, can be cast in the form of a system of first order hyperbolic equations. The difficulty associated with locking effects commonly encountere...

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

The heterogeneous fixed fleet open vehicle routing problem (HFFOVRP) is one of the most significant extension problems of the open vehicle routing problem (OVRP). The HFFOVRP is the problem of designing collection routes to a number of predefined nodes by a fixed fleet number of vehicles with various capacities and related costs. In this problem, the vehicle doesn’t return to the depot after se...