The aim of the present study was to assess the anticancer effect of several naftopidil analogues on human malignant mesothelioma cell lines NCI-H28, NCI-H2052, NCI-H2452, and MSTO-211H, human lung cancer cell lines A549, SBC-3, and Lu-65, human hepatoma cell lines HepG2 and HuH-7, human gastric cancer cell lines MKN-28 and MKN-45, and human bladder cancer cell lines 253J, 5637, KK-47, TCCSUP, T...

miR-126 is an endothelial-specific microRNA essential for governing vascular integrity and angiogenesis. Its role in tumor angiogenesis of gastric cancer (GC) is unclear. This study aimed at determining the role of miR-126 in GC angiogenesis. Down-regulation of miR-126 was found to inversely correlate with an increased microvessel density (MVD) and vascular endothelial growth factor A (VEGF-A) ...

We present near infrared data on the luminous interacting system Mkn 266 (NGC 5256), comprising 2 µm continuum, and Brγ and 1-0 S(1) emission line images, together with K-band spectra. We have fitted stellar templates to the continuum, allowing us to account for all the stellar features and hence detect even faint gas excitation emission lines, including 8 and 11 H 2 lines in the SW and NE nucl...

OBJECTIVE To investigate the effects of miR-106b on malignant characteristics of gastric cancer cells, and explore possible mechanisms. METHODS Expression of miR-106b, p21 and E2F was determined by real-time PCR. Transfection with miR-106b mimics was conducted, and gastric cancer cells with miR-106b overexpression were obtained. Cells transfected with mimic mutants and those without transfect...

We analyse the apparent disagreement between the mass estimates of the central black hole(s) in Mkn 501 based on (i) the observations of the host galaxy, (ii) the high energy (HE) emission mechanism, and (iii) the modulation of the beamed radiation by a black hole (BH) binary system. While method (i) seems to imply a central mass > ∼ 5 × 10 8 M⊙, method (ii) suggests a BH mass less than ≃ 6 × 1...

The infrared spectra of starburst galaxies are dominated by the low-excitation lines of [NeII] and [SIII], and the stellar populations deduced from these spectra appear to lack stars larger than about 35 M⊙. The only exceptions to this result until now were low metallicity dwarf galaxies. We report our analysis of the midinfrared spectra obtained with IRS on Spitzer of the starburst galaxy NGC ...

Gastric cancer cell are not particularly sensitive to Ara-C, a deoxycytidine analog that affects DNA synthesis. In the present study, AGS and MKN-45 gastric cancer cell lines were treated with Ara-C to determine its role in cell prolife-ration and apoptosis. The antiproliferative effect of Ara-C was assessed using the Cell Counting kit-8. Gelatinase zymography was utilized to detect the activit...