Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

Pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. In this study, B3 p 86 / 6 – 31 + + G * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. Several statisti...

Pythium is a fungus-like genus with worldwide distribution that is found in most terrestrial and aquatic ecosystems. It is a species-rich genus contains important plant pathogenic species. Little is known on the systematics of Pythium in West Azarbaijan province (N.W. Iran). Thus, the aim of this study was to identify 200 isolates collected from different cultivated soils of West Azarbaijan pro...

This paper looks at the present standing of ecommerce in Saudi Arabia, as well as the challenges and strengths of Business to Customers (B2C) electronic commerce. Many studies have been conducted around the world in order to gain a better understanding of the demands, needs and effectiveness of online commerce. A study was undertaken to review the literature identifying the factors influencing ...

Vision based bin picking is increasingly more di cult as the complexity of target objects increases We propose an e cient solution where complex objects are su ciently represented by simple features cues thus invariance to object complexity is established The re gion extraction algorithm utilized in our approach is capable of providing the focus of attention to the simple cues as a trigger towa...

We present preliminary work on automatically scoring constructed responses elicited as part of a certification test designed to measure the effectiveness of the test-taker as a K-12 music teacher. This content scoring differs from most previous work in that the responses are relatively long and are written by an adult population of generally proficient English writers. We obtain reasonably good...

We show that people’s travel destinations are predictable based on simple features of their home and destination. Using geotagged Twitter data from over 200,000 people in the U.S., with a median of 10 visits per user, we use machine learning to classify whether or not a person will visit a given location. We find that travel distance is the most important predictive feature. Ignoring distance, ...

The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has introduced as causative agent for coronavirus disease 2019 (COVID-19) since the 2019 December. Human coronaviruses are classified in Nidovirales order and Coronavirdiae family. This family includes four genera. The SARS-CoV-2 is a member of Betacoronavirus genera and Sarbecovirus linage (linage B). There is ...

an outbreak of malignant catarrhal fever (mcf), a fatal viral disease in indigenous tanzanian shorthorn zebu in ngorongoro district of tanzania during the period of june 2004 has been described. the disease was diagnosed by clinical, post mortem findings and the virus was identified using molecular characterization study. the history and clinical features included pyrexia, cornel opacity, nasal...