Background: There is an increase in the incidence of heart failure among sub-Saharan population. The use guideline-directed medical therapy has been shown not only to reduce disease progression but also frequent hospitalization, morbidity, and mortality from failure. This study was directed at identifying which major drug class for treatment incorporated by physicians area. Methodolog...

BACKGROUND Spironolactone, a nonselective mineralocorticoid receptor antagonist (MRA), may have a deleterious effect on glycemia. The objective of this review was to assess current knowledge on MRAs' influence (spironolactone, eplerenone, and canrenone) on glucose homeostasis and the risk of diabetes. METHOD A systematic review was conducted using the Medline database on articles published fr...

The Conventional control approach may not be suitable for non-linear systems and for the systems with considerable parameter variations over a period of time. On the other hand adaptive control techniques proved to be a convenient tool in dealing with the above said systems. The Model Reference Adaptive Systems (MRAS) with performance specifications given in terms of reference model is tried fo...

The Conventional control approach may not be suitable for non-linear systems and for the systems with considerable parameter variations over a period of time. On the other hand adaptive control techniques proved to be a convenient tool in dealing with the above said systems. The Model Reference Adaptive Systems (MRAS) with performance specifications given in terms of reference model is tried fo...

This paper presents a new algorithm based on Model Reference Adaptive System (MRAS) and its stability analysis for sensorless control of Doubly-Fed Induction Generators (DFIGs). The reference and adjustable models of the suggested observer are based on the active power of the machine. A hysteresis block is used in the structure of the adaptation mechanism, and the stability analysis is performe...

What is the best strategy to approve novel drugs for disease such as sleeping sickness that predominantly affect patients in Africa? How can African regulators best be supported to evaluate these drugs for their own populations? For many years, African medicines regulatory authorities (MRAs) have relied on stringent regulators in developed countries to assess novel pharmaceutical products such ...

Acute β-blockade with metoprolol has been associated with increased mortality by undefined mechanisms. Since metoprolol is a relatively high affinity blocker of β(2)-adrenoreceptors, we hypothesized that some of the increased mortality associated with its use may be due to its abrogation of β(2)-adrenoreceptor-mediated vasodilation of microvessels in different vascular beds. Cardiac output (CO;...