Editorials 78 The World Health Organization (WHO) and its partners have long conducted efforts to improve tuberculosis (TB) case surveillance and programme monitoring and evaluation. WHO's 2011 report on global TB control 1 provided the most reliable information ever generated on the burden of disease and death caused by TB and multidrug-resistant TB (i.e. disease marked by in vitro resistance ...

Multidrug resistance (MDR) in leukemia patients is a great incentive to the development of new drugs. In a search for potential multidrug resistance modulators we tested a group of oleanolic acid (OA) analogues modified at C-3, C-11, C-12 and C-28 using an experimental model consisting of three human acute lymphoblastic leukemia cell lines (CCRF-CEM and the multidrug resistant sublines CCRF-VC...

This prospective case-control study was conducted from October 2003 to June 2007 to evaluate risk factors for multidrug resistance among extended-spectrum-b-lactamase-producing Escherichia coli and Klebsiella spp. (ESBL-EK) isolates in blood cultures. All adult patients (>18 years old) whose blood cultures grew ESBL-EK during the study period were included. An ESBL-EK isolate was defined as MDR...

Abstract Introduction Escherichia coli is an opportunistic bacteria that can grow easily, produce toxins, and resist antibiotics. The phenomenon of E. developing multidrug resistance currently the subject extensive research. objective this study was to molecularly identify bla TEM CTX-M genes in multidrug-resistant found milk samples from dairy cattle farms Tulungagung, Indonesia. Material Meth...

The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resis...


 Introduction : Multidrug-resistant TB (MDR TB) is a type of that resistant to at least two the first-line antimicrobials, isoniazid (INH) and rifampin (RMP), with or without resistance other antimicrobials. The factors causing MDR-TB were age, gender, education level, income, occupation, medication adherence, knowledge, attitudes, stigma, smoking habits, role PMO, side effects treatment....

BACKGROUND The emergence of multidrug-resistant (MDR) Acinetobacter baumannii as an important opportunistic pathogen has given rise to significant therapeutic challenges in the treatment of nosocomial infections. In the present study, we assess the antibiotic resistance mechanisms of MDR A. baumannii strains by estimating the prevalence of antibiotic resistance determinants, including integrons...

The emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) in Acinetobacter baumannii has made an important challenge in the treatment of infections caused by this organism. The ability of carbapenemase production is one of the main mechanisms for the emergence of MDR and/or XDR in A. baumannii. The aim of this study was to detect carbapenemase producer A. baumannii. In t...

Steiger, Scott, MS., May 2013, Major Medicinal Chemistry 4-Isoxazolyl-1,4-dihydropyrirines bind the multidrug-resistance transporter Chairperson: Nicholas R. Natale The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variet...

China and became a professor since 2002. Dr. Fu has long standing research interests in cancer pharmacology and chemotherapy, especially the cancer multidrug resistance and TKIs' resistance as well as personalized chemotherapy. His original contribution includes establishing tumor living tissue susceptibility system in vitro, discovering drugs targeting ABC transporters to reversing MDR, and de...