Nucleus accumbens (Nac) has been considered as a center for the induction of drug dependence. Since a high concentration of the enzyme, nitric oxide synthase (NOS) has been found in the Nac, and this fact that the role of nitric oxide (NO) in acquisition and expression of drug dependence has become clear in recent years, therefore in this study the effects of intraaccumbal injections of L-argin...

L-Arginine is the common substrate for two enzymes, arginase and nitric oxide synthase (NOS). Arginase converts L-arginine to L-ornithine, which is the precursor of polyamines, which are essential components of cell proliferation. NOS converts L-arginine to produce NO, which inhibits proliferation of many cell lines. Various human breast cancer cell lines were initially screened for the presenc...

objective(s) the process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. systemic administration of l-arginine promotes wound healing but its global side effects are undesirable. to confine the action of l-arginine at the site of injury, we tested the effects of local administration of l-arginine on the healing of excision...

nucleus accumbens (nac) has been considered as a center for the induction of drug dependence. since a high concentration of the enzyme, nitric oxide synthase (nos) has been found in the nac, and this fact that the role of nitric oxide (no) in acquisition and expression of drug dependence has become clear in recent years, therefore in this study the effects of intraaccumbal injections of l-argin...

L-Arginine is the common substrate for two enzymes, arginase and nitric oxide synthase (NOS). Arginase converts L-arginine to L-ornithine, which is the precursor of polyamines, which are essential components of cell proliferation. NOS converts L-arginine to produce NO, which inhibits proliferation of many cell lines. Various human breast cancer cell lines were initially screened for the presenc...

introduction: nitric oxide (no), as a free radical, involves in several physiologic functions in gi tract such as nerve impulse transmission and vascular tonicity regulation. nitric oxide synthase (nos) is the enzyme for the production of no from l-arginine which in turn inhibits by l-ngnitroarginine methyl ester (l-name). in the current work, we aimed to evaluate morphometric analysis of duode...

introduction: the aim of the present study was to evaluate the effect of exercise training and l-arginine supplementation on oxidative stress and systolic ventricular function in rats with myocardial infarction (mi). methods: four weeks after the surgically-induced mi, 40 male wistar rats were randomly assigned to the following 4 groups (n=10): mi-sedentary control (sed) mi-exercise (ex) mi-sed...

Increased production of nitric oxide (NO) and subsequent local cytotoxicity to mucosal epithelial cells has been proposed as a putative mechanism involved in the development of necrotizing enterocolitis (NEC). Intestinal epithelial cells (IECs) metabolize L-arginine to either nitric oxide (NO) by NO synthase (NOS) or to L-ornithine and urea by arginase. L-ornithine is the first step in polyamin...

BACKGROUND Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, a polypeptide containing 112 amino acids, which is secreted mainly by skeletal muscle cells during exercise, exerts a protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin...