Protein scaffolds are essential for specific and efficient downstream signaling at synapses. Though nicotinic receptors are widely expressed in the nervous system and influence numerous cellular events due in part to their calcium permeability, no scaffolds have yet been identified for the receptors in neurons. Here we show that specific members of the PSD-95 family of PDZ-containing proteins a...

The pyridine moieties of the pyridine nucleotides, nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, and nicotinamide adenine dinucleotide, were shown to be incorporated into ricinine by Ricinus communis L. with an efficiency comparable to that of quinolinic acid, nicotinic acid, and nicotinamide, which had been established previously as being efficient precursors of this alka...

Neuronal nicotinic acetylcholine receptors are distributed extensively throughout the central and peripheral nervous systems. Currently, there is great interest in determining the structural and functional diversity of these receptors, and in developing subtype-selective agonists that have potential as therapeutic agents for neuropathology and disease. However, relatively little attention has b...

Yeasts utilize tryptophan for the synthesis of nicotinic acid under aerobic, but not under anaerobic, conditions. Under aerobic conditions of growth, radioactivity from tryptophanJ4C uniformly labeled in the benzene ring and 14C!-carboxyl-labeled 3-hydroxyanthranilic acid is incorporated into nicotinic acid. Under anaerobic conditions, little radioactivity from these compounds is incorporated i...

The identification of a family of neuronal nicotinic receptor subunit genes establishes the potential for multiple subtypes with diverse physiological functions. Virtually all of the high affinity nicotinic receptors measured to date in the rodent CNS are composed of alpha4 and beta2 subunits only. However, the demonstration of other subunit transcripts in a variety of central and peripheral ne...

lbogaine noncompetitively blocked (IC,, 20 nM) “NaCI influx partially reversible in PC12 ceils. In viva, ibogaine at 10 mg/kg through ganglionic-type nicotinic receptor channels of rat completely blocked epibatidine-elicited antinociception in rheochromocytoma PC1 2 cells. The major metabolite O-desmice, a response that is mediated by central nicotinic receptor ;I-~ethylibogaine was 75fold less...

Dear Editor, Nicotinamide with tetracycline or doxycycline is used in the treatment of bullous pemphigoid. Nicotinamide is used in doses of 1500 to 2000 mg/day in divided doses in these cases. Nicotinic acid/laropiprant (Tredaptive®) is a lipid lowering agent which contains 1000 mg of nicotinic acid (niacin) and 20 mg of laropiprant which is a selective antagonist of prostaglandin D2 receptor. ...

Nicotine increases the permeability of the blood-brain barrier in vivo. This implies a possible role for nicotinic acetylcholine receptors in the regulation of cerebral microvascular permeability. Expression of nicotinic acetylcholine receptor subunits in cerebral microvessels was investigated with immunofluorescence microscopy. Positive immunoreactivity was found for receptor subunits alpha3, ...