OMID SHAKERNIA is a senior researcher at Research Affiliates, LLC, in Newport Beach, CA. [email protected] Traditional strategic asset allocation theory is deeply rooted in the mean–variance portfolio optimization framework developed by Markowitz [1952] for constructing equity portfolios. However, the mean–variance optimization methodology is diff icult to implement due to the challenges asso...

background: metastatic prostate cancer is one of the most important cancers among men worldwide. androgen ablation therapy can be used in treatment of these patients; however, most will progress to metastatic hormone-refractory prostate cancer. in this regard, docetaxel has been approved to treat metastatic hormone-refractory prostate cancer in the united states. in this study, we aimed to inve...

Atopic eczema (AE) is a chronic inflammatory skin disease, characterized by intense itching, dry skin, infiltration of immune cells and skin lesions. To date, the cause of AE, a disease affecting 15-30% of children and 210% of adults, remains unknown and the pathomechanisms are not fully understood. Many factors, however, have been implied to contribute to this complex disorder, such as genetic...

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Introduction Increase in unemployment rate, along with growing resource depletion, is one of the economic-cultural challenges of many developing countries, including Iran. These problems are more deep and complex in rural areas. In other words, our society has been suffering from a lack of production for many years, and consequently, a high unemployment rate in rural areas, which has led to an...

introduction: esophageal cancer is a common gastro intestinal malignancy. one of the most common techniques of surgery in esophageal cancer is transhiatal esophagectomy with esophagogastric anastomosis in the neck. this technique is accompanied by complications like chronic gastero-esophegeal reflux and late stenosis. this study was designed to compare the risk of complications after two surgic...

background and purpose: the goal of this study is application of the proportional hazards model (ph) and accelerated failure time model (aft), with consideration weibull distribution, to determine the level of effectiveness of the factors affecting on the level of disease-free survival (dfs) of the patients with breast cancer. materials and methods: based on the retrospective descriptive studie...

the aim of this study was to determine the structural equation model of knowledge management and organizational innovation. the statistical population consisted of all employees of sport and youth offices in khorasan razavi province (n=380). the sample was selected by simple random sampling method using morgan table (n=191). to collect data, two questionnaires of knowledge management (sheron an...

introduction: caustic ingestion is responsible for a spectrum of upper gastrointestinal tract injury from self-limited to perforation. this study conducted to evaluate clinical characteristics as well as surgical outcomes in patients with caustic ingestion.   materials and methods: between nov1993 to march 2011, 14 adults with a clinical evidence of corrosive ingestion were admitted into our in...

introduction: diaphragmatic hernia could be caused by congenital disorders, blunt trauma or penetrating injuries. the diagnosis of traumatic diaphragmatic hernia is normally neglected during the first presentation leading to late complications and considerably increased mortality and morbidity among the patients. materials and methods: in this retrospective, descriptive study, we reviewed the m...