نتایج جستجو برای: oprm1 gene
تعداد نتایج: 1141821 فیلتر نتایج به سال:
Scientific understanding of social pain--the hurt feelings resulting from social rejection, separation, or loss--has been facilitated by the hypothesis that such feelings arise, in part, from some of the same neural and neurochemical systems that generate the unpleasant feelings resulting from physical pain. Accordingly, in animals, the painkiller morphine not only alleviates the distress of ph...
The agonists of mu-opioid receptor (OPRM1) induce extracellular signal-regulated kinase (ERK) phosphorylation through different pathways: morphine uses the protein kinase C (PKC)-pathway, whereas fentanyl functions in a beta-arrestin2-dependent manner. In addition, the two pathways result in the different cellular location of phosphorylated ERK and the activation of different sets of transcript...
Respiratory depression is a common adverse effect of propofol and remifentanil. We aimed to develop a model for respiratory depressant effects of propofol with remifentanil in patients undergoing endoscopy with sedation. Data were available for 136 patients undergoing endoscopy with sedation. Participants randomly received infusions of propofol and remifentanil. Predicted plasma concentrations,...
All circadian clock genes discovered in Drosophila have mammalian counterparts with extensive sequence homology. Similarities and differences have been identified between insect and mammalian oscillators. Recent studies have shed new light on two mammalian clock components: Mop3 and Per2.
SNPs of OPRM1, resulting in amino acid changes the protein sequence (e.g., N40D), may have effects pain and reward processing. Epigenetic changes, as well positive negative transcription factors, are key controllers receptor expression. Alternative splicing generates over 20 different isoforms mu-opioid (MOR) with distinct pharmacological characteristics; these include 7-TM, 6-TM, 1-TM. MicroRN...
هدف از این مطالعه بررسی فراوانی پلی مورفیسم تک نوکلئوتیدی a118g در ژن رمز کننده گیرنده میو در مسمومین با اپیوئیدهای متفاوت و ارزیابی ارتباط آن با متغیر¬های مختلف بود. علائم بالینی، علائم حیاتی و مشخصات دموگرافیک در مسمومین با اپیوئیدها مورد بررسی قرار گرفت. از تعداد 60 فرد مسموم با اپیوئیدها پس از کسب رضایت کتبی به مقدار 5 میلی لیتر خون محیطی با روش استریل گرفته شد و استخراج dna با استفاده از ک...
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