Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function and persistent symptoms. Current therapies do not adequately treat the structural airway changes associated with asthma. Statin drugs have improved respiratory health and their therapeutic potential in asthma has been tested in clinical trials. However, the mechanism of action of statins in this context has...

Results: Morphine (1-10 mg/kg) inhibited ovalbumin-evoked increase in microvascular plasma leakage in a dosedependent manner; however, it had no significant effect at the doses of 0.1 or 30 mg/kg. In addition, morphine, at the doses of 1-30 mg/kg, abolished microvascular leakage increased by capsaicin. The inhibition caused by morphine was blocked by the peripheral opioid receptor antagonist, n...

The isoelectric point of ovalbumin has been determined a number of times by different methods and investigators with widely varying results (pH 4.55 to 4.88). In order to determine whether the variations of the values reported could be due to the influence exerted by the ionic strength of the buffer solvent and perhaps that of the protein itself, the writer has made a study of different concent...

1H and 31P NMR spectroscopies have been used to examine the effects of limited proteolysis with subtilisin Carlsberg on the global conformation of ovalbumin and on the local environment of phosphoserine 344, a residue two positions removed from the site of proteolysis. Such limited proteolysis has been shown to result in excision of a hexapeptide from the region of the protein that, in other se...