Abstract A variety of associations between cutaneous manifestations and myelodysplastic syndrome (MDS) have been described, but the frequency is unknown. The presence may therapeutic prognostic significance, as thereof has reported to be associated with poor prognosis or acute myeloid leukaemia (AML) progression, precede diagnosis MDS [Farah C, Bulai Livideanu Jegu J et al. Prevalence value in ...

Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) characterized by abnormal megakaryoblasts that expressplatelet-specific surfaceglycoprotein.Bonemarrowbiopsy frequently demonstrates extensive myelofibrosis, often making aspiration in these patients difficult. AMKL is extremely rare in adults, occurring in only 1% of AML patients. This is in contrast to childre...

Thirty cases of newly diagnosed pediatric acute myeloblastic leukemia (AML) with French-American-British (FAB) M2 morphology were analyzed with cytogenetics and a comprehensive panel of monoclonal antibodies reactive with lymphoid-, natural killer (NK)-cell-, and myeloid-associated antigens. The t(8;21)(q22;q22), or t(8;21;V)(q22;q22;V), translocation was identified in 16 of the 30 cases. Cases...

Marjolein Blink, Marry M. van den Heuvel-Eibrink, Valerie de Haas, Jan-Henning Klusmann, Henrik Hasle, and C. Michel Zwaan Department of Pediatric Oncology/Hematology, Erasmus MC–Sophia Children’s Hospital Rotterdam, The Netherlands; Dutch Childhood Oncology Group, The Hague, The Netherlands; Department of Pediatric Oncology/Hematology, AML-BFM Study Group, Medical High School, Hannover, German...

FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found FLT3/ITDs in 11.5% of 234 children with de novo AML. FLT3/ITD-positive patients were significantly older and had higher percentages of normal cytoge...

Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal transformation of hematopoietic precursors through the acquisition of chromosomal rearrangements and multiple gene mutations. As a result of highly collaborative clinical research by pediatric cooperative cancer groups worldwide, disease-free survival has improved significantly during the past 3 decades. ...

FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found FLT3/ITDs in 11.5% of 234 children with de novo AML. FLT3/ITD-positive patients were significantly older and had higher percentages of normal cytoge...

De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing the e6a2 fusion transcript and describe disease sensitivity to both imatinib bef...

Acute myeloid leukemia (AML) is a heterogeneous disease that includes subsets with distinct biological, clinical and prognostic features. It has been well established that cytogenetic abnormalities at diagnosis are associated with the biology of the disease and have important prognostic implications. The coexistence of multiple cytogenetic abnormalities designated as complex karyotype (CK) has ...