1 DDS, PhD, Professor, School of Dentistry, Federal Fluminense University (UFF), Nova Friburgo, Rio de Janeiro, Brazil. 2 DDS, MS, Doctorate student, Department of Clinical Analysis, School of Pharmaceutical Sciences, Univ. Estadual Paulista UNESP, Araraquara, São Paulo, Brazil 3 DDS, PhD, Professor, Department of Physiology and Pathology, Araraquara School of Dentistry, Univ. Estadual Paulista...

714. Development of an Evidence-Based Antimicrobial Stewardship Smartphone App in a Tertiary Academic Pediatric and Women’s Health Centre in Canada Kathryn Slayter, BScPharm, PharmD; Jennifer Turple, BScPharm; Jeannette L. Comeau, MD, MSc; Karina A. Top, MD, MS; Joanne M. Langley, MD, FRCPC, FSHEA; Tim Mailman, MD and Scott A. Halperin, MD; IWK Health Centre, Halifax, NS, Canada, Dalhousie Univ...

Sharon E. Mace, MD, Chair, American College of Emergency Physicians (ACEP) Isabel A. Barata, MD (ACEP) Joseph P. Cravero, MD (American Society of Anesthesiologists) William C. Dalsey, MD (ACEP) Steven A. Godwin, MD (ACEP) Robert M. Kennedy, MD (American Academy of Pediatrics) Kelly C. Malley, CPNP, RN (Emergency Nurses Association) R. Lawrence Moss, MD (American Pediatric Surgical Association) ...

The unbound drug hypothesis states that only unbound drug concentrations are active and available for clearance, and highly variable results regarding unbound vancomycin fractions have been reported in the literature. We have determined the unbound vancomycin fractions in four different patient groups by a liquid chromatography tandem mass spectrometry (LC-MS/MS) method and identified factors t...

Retinal ganglion cells (RGCs) receive input from photoreceptive cells, have unmyelinated axons that constitute the retinal nerve fiber layer (RNFL), and gain myelin as they pass through the lamina cribrosa to form the optic nerve. RGC axons project to several structures within the CNS, including the lateral geniculate nucleus of the thalamus. The ganglion cell layer (GCL) constitutes a readily ...

A prospective study was performed to determine the value of direct molecular testing of whole blood for detecting the presence of culturable and unculturable bacteria and yeasts in patients with suspected bloodstream infections. A total of 464 adult and pediatric patients with positive blood cultures matched with 442 patients with negative blood cultures collected during the same period were re...

OBJETIVE To study the association between the metabolic syndrome (MS) and the glycemic load (GL) of food intake among obese children and adolescents seen in consultation by the endocrinology team in a pediatric referral hospital in Lima, Peru. POPULATION AND METHOD Cross-sectional study among obese children and adolescents (body mass index ≥ 95 percentile), 10-15 years old. The MS was classif...

B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process. One candidate autoantigen for multiple sclerosis (MS) is myelin oligodendrocyte glycoprotein (MOG). MOG is localized at the outermost surface ...

BACKGROUND/PURPOSE Since 1985, a nationwide mass screening program (MS) for neuroblastoma has been conducted for 6-month-old infants throughout Japan, resulting in the detection of more than 1,900 cases of neuroblastoma. The outcome of these patients has been excellent: more than 97% of them are alive. Yet, several reports suggest that the number of advanced-stage neuroblastoma patients over 1 ...