Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema following a significant CNS insult. The cause is believed to be a surge of catecholamines that results in cardiopulmonary dysfunction. Although there are myriad case reports describing CNS events that are associated with this syndrome, few studies have identified specific treatment modali...

After the accidental injection of epinephrine into a digit, various techniques to try and reverse the ensuing ischaemia were unsuccessful. To identify a further treatment strategy and as members of the admitting team were unfamiliar with digital injection of epinephrine a Google search was performed. Previous cases were described and separate sources indicated appropriate management protocols u...

Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine inject...

SUMMARY A further instance of the successful removal of a phaeochromocytoma is reported and it is suggested that halothane, despite theoretical contraindications, may be the anaesthetic agent of choice for this procedure. The possible value of (a) prolonged pre-operative preparation with either oral phentolamine or phenoxybenzamine with or without pronethalol, (b) pre-operative blood volume stu...

In two groups of dogs we studied the effect of right and/or left stellectomy on myocardial reactive hyperemia (RH) and on coronary blood flow distribution. In the first group of 14 conscious dogs, the percent repayment of flow debt produced by a 10-second occlusion of the left circumflex coronary artery was recorded with a Doppler ultrasonic flow probe and a hydraulic vascular occluder. The dog...

1. The effect on rectal temperature of adrenoceptor blocking agents, injected through a cannula chronically implanted into a lateral cerebral ventricle, was examined in unanaesthetized rabbits, cats and rats, kept at room temperature (19-22 degrees C).2. In rabbits, the alpha-adrenoceptor blocking agent phenoxybenzamine (50 or 100 mug) produced marked hypothermia when injected intraventricularl...

Following an increase in the number of patients attending the accident and emergency department because of accidental injection of adrenaline from autoinjector devices prescribed for patients with severe allergic reactions, a review of published reports was undertaken to identify the best form of treatment. Local injection of phentolamine is effective for up to 13 hours after the inadvertent di...