In idiopathic portal hypertension (IPH) typical vascular lesions are present in the branches of the portal vein or in the perisinusoidal area of the liver. Similar histological alterations have been reported in the pulmonary vasculature of patients with idiopathic pulmonary artery hypertension (IPAH). As IPAH is associated with mutations of the bone morphogenetic protein receptor 2 (BMPR2) gene...

Most double-stranded DNA viruses package genetic material into empty precursor capsids (or procapsids) through a dodecameric portal protein complex that occupies 1 of the 12 vertices of the icosahedral lattice. Inhibiting incorporation of the portal complex prevents the formation of infectious virions, making this step an excellent target for antiviral drugs. The mechanism by which a sole porta...

Objective(s): An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO overproduction, we aimed to examine its role in a rat model of CCl4-induced cirrhotic cardiovascular complications. Materials and Methods: Portal pressure and inotropic responsiveness of isolated papillary muscles to is...

umbilical and supraumbilical catheter insertion is a common procedure performed in the nicu. it is a safe and usually easy procedure devoid of serious mishaps, morbidity and mortality. complications such as hemorrhage, infection, hernia, evisceration, omphalitis, portal vein thrombosis and portal hypertension may occur after umbilical catheter insertion. other uncommon and rare complications re...

BACKGROUND Patient portal adoption has rapidly increased over the last decade. Most patient portal research has been done in primary care or medical specialties, and few studies have examined their use in surgical patients or for recruiting research subjects. No known studies have compared portal messaging with other approaches of recruitment. OBJECTIVES This case report describes our experie...

In this paper, firstly, in $E_1^3$, we defined normal Fermi-Walker derivative and applied for the adapted frame. Normal Fermi-Walker parallelism, normal non-rotating frame, and Darboux vector expressions of normal Fermi-Walker derivative by normal Fermi-Walker derivative are given for adapted frame. Being conditions of normal Fermi-Walker derivative and normal non-rotating frame are examined fo...

Two dissimilar hemodynamic hypotheses, the "backward flow" theory and the "forward flow" theory, have been advanced to define splanchnic hemodynamics in portal hypertension. An animal model with portal hypertension and high-grade portal-systemic shunting, the portal vein-stenotic rat, was studied to determine whether a hemodynamic picture compatible with either theory would develop. Splanchnic ...