BACKGROUND Premature ovarian failure (POF) before 40 years of age from natural causes affects approximately 1% of adult women, with minor variations between ethnic groups. A recent case of ovarian transplantation between young monozygotic (MZ) twins in which one had undergone unexplained POF at 14 years has prompted a study of the prevalence of POF. METHODS Menopausal ages of 832 Australian a...

In women, around 10% of cancers occur in those younger than 45 years old. Although aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure more than 90% of girls and young women affected by disorders requiring such treatment, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Therefore, these treatments can result in premature ovarian failu...

OBJECTIVE To establish the risk associated with mutations in the coding region of GDF9 gene in Indian women with ovarian failure. DESIGN This case-control study was designed for mutational analysis of the GDF9 coding region in a cohort of women with premature ovarian failure (n = 127), primary amenorrhea (n = 58), and secondary amenorrhea (n = 10) compared with controls (n = 220). RESULTS T...

When we use the term “premature menopause” or climacterium praecox, we mean cessation of the normal cyclic ovarian function prior to the age of 40. Some authors have defined the limit at an even earlier age, namely 35 and in some cases even 30 [1]. Especially in young women, speaking of a prema­ ture menopause often causes problems for psychological reasons. The thought of being menopausal at s...

It is now recognized that female carriers of fragile X premutations are at increased risk of premature ovarian failure. We have studied 51 premenopausal women from fragile X families, to determine whether premutation carriers have variations in the hormonal markers of menopause, compared to full mutations and controls. We found a significant increase in serum follicle stimulating hormone in pre...

Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotox...

We describe two cases of left-sided ovarian varicocele in patients with infertility. Pregnancy occurred in both women after successful retrograde venous embolization. Ovarian varicocele may be associated with infertility in some patients.

Ovarian turnoues are seen in females of any age. Although ovarian tumours account for 1 2% of all tumours in childhood, the most frequent are germ-cell tumours and 20% of them are malignant during the first decade of life. The youngest female with an ovarian tumour recorded was in a 30-week old foetus.' The youngest female with a benign cystic teratoma has been reported to be 16-months old. We ...

We present 2 cases of likely rare event. In case 1, 3rd degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. The same inv(6) being inherited in progeny but presented with low AMH (anti Mullerian hormone) and high level of FSH (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. ...