Prolonged endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) have been linked to apoptosis via several mechanisms, including increased expression of C/EBP homologous protein (Chop). Increased long-chain fatty acids, in particular saturated fatty acids, induce ER stress, Chop expression, and apoptosis in liver cells. The first aim of the present study was to ...

16 Prolonged endoplasmic reticulum (ER) stress and activation of the unfolded protein response 17 (UPR) have been linked to apoptosis via several mechanisms including increased expression of 18 C/EBP homologous protein (Chop). Increased long-chain fatty acids, in particular saturated fatty 19 acids, induce ER stress, Chop expression and apoptosis in liver cells. The first aim of the present 20 ...

Systemic amyloidosis is recognized as a serious complication of rheumatoid arthritis or inflammatory bowel disease, but also skin disease. However, the detailed molecular mechanism associated with cutaneous inflammation remains unclear, and therapeutic approaches are limited. Here, we investigated pathophysiology secondary to effects Janus kinase (JAK) inhibitors by examining mouse model sponta...

Interleukin-27 (IL-27) is known to control primary CD4(+) T cell responses during a variety of different infections, but its role in regulating memory CD4(+) T responses has not been investigated in any model. In this study, we have examined the functional importance of IL-27 receptor (IL-27R) signaling in regulating the formation and maintenance of memory CD4(+) T cells following malaria infec...

background: despite major progress in our general knowledge related to the application of adult stem cells, finding alternative sources for bone marrow mesenchymal stem cells (mscs) has remained to be challenged. in this study successful isolation, multilineage differentiation, and proliferation potentials of sheep mscs derived from bone marrow, adipose tissue, and liver were widely investigate...

background: pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer cells population in the pregnant mice that needs to be investigated. objective: the aim of this study was to determine the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer ...

quantum dots are new types of fluorescent materials for biological labeling. as a result, qds toxicity study is an essential requirement for future clinical applications. therefore, the cytotoxic cdse:zns quantum dots effects on some organs in mice are presented in this study. in this work, 10, 20 and 40 mg/kg doses of cdse:zns quantum dots were injected to 32 adult male mice. structural and op...

Fifteen nude mice were inoculated with a human neuroblastoma cell line and 14 with a human primary hepatocellular carcinoma cell line. Human ferritins were detected in the sera of the mice which developed tumors. Of 14 mice bearing human neuroblastoma, 12 had human liver-type ferritin (8 to 52 ng/ml) in their sera, and three of these also had HeLa-type ferritin (acidic ferritin) (29 to 40 ng/ml...