Ninety-seven patients with 118 sites infected with Neisseria gonorrhoeae were treated with a single dose of either procaine penicillin G (4.8 x 10(6) U) or cefotoxime (1.0 g) intramuscularly. Only the penicillin group took 1 g of probenecid orally. The numbers of infected sites in each treatment group were as follows: penicillin-urethra, 37; rectum, 9; cervix, 8; and pharynx, 4; cefotaxime-uret...

The concentrations of penicillin in the cerebrospinal fluid (CSF) were compared simultaneously with those in the serum in 17 patients with syphilis. The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procai...

There have been some recent studies on the clinical uses of the antihistamines as local anesthetic agents (1, 2, 3, 4). These have included the use of the antihistamines as local anesthetics for minor surgical procedures, nerve blocks and spinal anesthesia. The authors have compared the particular antihistamines under evaluation to procaine and, in general, have obtained results superior to tho...

The interactions of veratridine, cevadine, veracevine, and veratramine with monolayers of stearic acid show marked differences. Veratridine and cevadine, at concentrations that are known from potential, ionic flux, and other measurements to affect living membranes, react strongly with the film and appear to cause an "interfacial dissolution" whereby both the alkaloid and the stearate leave the ...

Synaptic transmission was studied in giant synapses of the stellate ganglion of the squid. When bathed in air-saturated sea water, the synapses deteriorate in 10 to 20 min.; if the sea water is saturated with 100 per cent oxygen, they function steadily for up to 12 hours. Optimal results probably require a medium with lower magnesium and higher calcium than the sea water used. Of eighteen compo...