B. Turrin et al. (1) argue that conventional K-Ar and 4Ar/39Ar age determinations and paleomagnetic data provide a definitive age assignment of approximately 136 ka (thousand years ago) to 141 ka for the Lathrop Wells volcanic center with an error of less than 10,000 years. This conclusion is tendered despite replicate age determinations that extend over almost three orders of magnitude. Turrin...

I diopathic epilepsies have a genetic basis and are characterised by the absence of an overt underlying neurological abnormality. Most idiopathic epilepsies are complex diseases with considerable clinical and genetic heterogeneity and an unclear inheritance pattern because of genetic and environmental factors. Families in which the disease segregates as an autosomal dominant trait with reduced ...

pelling, particularly in an era in which treatment of chronic diseases is consuming more of the health care dollar and more senior citizens need care. But financial incentives for physicians to return to black bag and horse-and-buggy medicine haven’t followed suit. “The majority of family doctors don’t make home visits. So these seniors sort of slip through the cracks until there’s a crisis and...

Economists and economic historians have generally understood different forms of land tenure as arrangements for the supply of labor. This paper suggests a different interpretation—that land-tenure arrangements be understood rather as arrangements for the supply of financing. The cost and availability of financing depend on the arrangements available to ensure the providers of the financing a fa...

Huntington's disease (HD) is an inherited and incurable neurodegenerative disorder characterized by marked striatal atrophy. Adenosine receptors may represent a possible therapeutic target for HD. The localization of A2A receptors (A2ARs) in medium-sized spiny neurons, which are selectively lost in HD suggested that these receptors could play an important pathogenetic role. Unfortunately, confl...

N ine neurodegenerative diseases are caused by expanding CAG repeats coding for polyglutamine (polyGln) (1–4). These include Huntington’s disease, dentatorubral and pallidoluysian atrophy, several forms of spino-cerebellar ataxia, and spinal and bulbar muscular atrophy. Within the central nervous system, each disease has a distinctive pattern of degeneration, with considerable overlap among the...

R obin sequence (RS) is a developmental malformation characterised by micrognathia, cleft palate, and glossoptosis, leading to respiratory and feeding difficulties in the majority of affected neonates. 2 These three features constitute the primary diagnostic criteria of RS, although diagnosis on the basis of any two of these three classical features has been suggested. Typically the condition o...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) (previously referred as blastic natural killer cell leukemia/lymphoma or agranular CD4+/CD56+ hematodermic neoplasm) is a rare hematologic malignancy derived from the precursors of plasmacytoid dendritic cells and is now classified as a rare subtype of acute myeloid leukemia according to the 2008 WHO classification. The disease is a clinicall...