BACKGROUND Autophagy is a biological process during which cells digest organelles in their cytoplasm and recycle the constituents. The impact of autophagy in the heart, however, remains unclear in part because of the inability to noninvasively image this process in living animals. METHODS AND RESULTS Here, we report the use of fluorescence molecular tomography and a cathepsin-activatable fluo...

N-RAP is an actin binding LIM protein expressed in skeletal and cardiac muscle tissues (Luo et al., 1997). In adult mice, N-RAP is found at the longitudinal ends of striated muscles at sites of mechanical coupling between the myofibrils and the cell membrane (Luo et al., 1997). These regions are the myotendinous junctions in skeletal muscle and the intercalated disks in heart muscle, and ultras...

Homicide is a rare event, but depictions of it are quite common in our culture and discourse. Commercially successful rappers have appropriated homicide as a central theme in their lyrical compositions. The tremendous success of rap music is indicative of its increasing popular appeal and cultural impact. We reveal the ways homicide is constructed within rap music and its frequency of occurrenc...

The impact of RAP on water was identified to be analyzed for the material's resistance because there are still a lot waterlogged pavements in Indonesia. This research uses variation 0%, 25% and 35%. test is Marshall get optimum asphalt content value, Cantabro determine weight loss 300 rounds durability by varying immersion 0.1, 2, 4 7 days which will tested ITS. KAO value obtained each 5.4% 0% ...

OBJECTIVE Little is known about prevalence and usual treatment of childhood and adolescent recurrent abdominal pain (RAP) in outpatient paediatricians' practice. This study's primary objective was to acquire insights into the usual paediatricians' treatment and their estimation of prevalence, age and gender of RAP patients. Further objectives were to assess to which extent family members of pat...

RAP aims to refine protein secondary structure prediction from one of famous prediction tools. Protein secondary structure prediction has been extensively discussed for almost 50 years and the machine learning is one of feasible methods for it with more than 70% accuracy. PSIPRED, PHD and PROF are well-known machine learning approaches and based on the three-state prediction: helix, strand, and...

BACKGROUND Central venous pressure (CVP) and right atrial pressure (RAP) are important parameters in the complete hemodynamic assessment of a patient. Sonographic measurement of the inferior vena cava (IVC) diameter is a non-invasive method of estimating these parameters, but there are limited data summarizing its diagnostic accuracy across multiple studies. We performed a comprehensive review ...

MIA/CD-RAP is a small, soluble protein secreted from malignant melanoma cells and from chondrocytes. Recent evidence has identified MIA/CD-RAP as the prototype of a small family of extracellular proteins adopting an SH3 domain-like fold. It is thought that interaction between MIA/CD-RAP and specific epitopes in extracellular matrix proteins regulates the attachment of tumor cells and chondrocyt...

OBJECTIVE To determine whether medically unexplained recurrent abdominal pain (RAP) in childhood predicts abdominal pain, irritable bowel syndrome (IBS), other somatic complaints, and psychiatric symptoms and disorders in young adulthood. METHODS A sample of 28 young adults evaluated for RAP between the ages of 6 and 17 years were compared with 28 individually matched former childhood partici...