Objective- To evaluate antinociceptive efficacy of pre- versus post-incisional morphine, tramadol and meloxicam using tail-flick test in an incisional model of pain in rats. Design- Prospective, randomized experimental study. Animals- Eighty, adult, male Wistar rats weighing 250–300 g. Procedures- Animals were randomly divided into eight groups to receive pre- or post-incisional (tail skin i...

Abstract —The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not fully understood. To further clarify role brain serotonergic (5-HT) activity action drugs, optogenetic inhibition 5-HT neurons rat dorsal raphe nucleus (DRN) was applied. In control animals, a subanesthetic dose alleviated their depressive-like behavior tail suspension test. Inhibit...

Interest in hydroxy - carboxylic acid 2 (HCA2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. The present study aimed to evaluate the presence of mRNA of this receptor in different organs of laboratory rat. Twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...

In the present study, the analgesic and anti-inflammatory activities of a new alkaloid (5′-Hydroxymethyl-1′-(1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida cordifolia Linn. was investigated in animal models. The analgesic activity was investigated in the acetic acid induced writhing and the radiant heat tail flick model in mice a...

Mixed xenogeneically reconstituted mice (F344 rat + C57BL/10Sn----C57BL/10Sn), which specifically retain F344 tail skin xenografts, were studied for the specificity of such hyporeactivity and for in vitro reactivity and immunocompetence. Survival of mixed reconstituted animals was excellent, without evidence for graft vs. host disease. Donor-type tail skin grafts were specifically prolonged (me...

bulbospinal noradrenergic pathways are shown to have an important role in descending inhibition of pain sensation. locus ceruleus (lc), as a rich noradrenergic nucleus in the brain stem which has projections into the dorsal horn of the spinal cord, was evaluated for antinociceptive activity by using tonic and phasic pain models in the rat. lc-lesioned rats demonstrated moderate increase in both...