background: in order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (ntcp), we consider the fractional dependence of the ntcp on the wall thickness (tw) and rectal displacement (rm). materials and methods: the two-dimensional ntcp model (ntcp2d) was developed using radiotherapy plans of ten randomly selected patients with prostat...

Tumor detection prior to invasion through the muscularis propria and before lymph node metastases appear offers the best prognosis and permits more limited surgery.2 Anterior or abdominoperineal resection is the standard treatment for rectal tumors, although a greater proportion of resections are now sphincter-saving or involve local excision.3,4 Despite surgical advances, local recurrence rate...

AIM The value of grading tumor regression after neoadjuvant therapy of rectal carcinoma was evaluated. PATIENTS AND METHODS Analysis was carried out using prospective data of 225 patients with rectal carcinoma treated by neoadjuvant radiochemotherapy followed by radical resection with curative intent. For the histological regression grading, the method of Dworak et al. (1997) was used with a ...

Gastrointestinal metastases from invasive lobular breast cancer are uncommon with the stomach and small intestines being the most common metastatic sites. Peritoneal and rectal metastases are very rare and only rarely occur as the first manifestation of disease. We herein report the case of a 47-year-old woman who presented with abdominal carcinomatosis as a first sign of invasive lobular breas...

A free screening clinic for cancer of the prostate was held in Madison County, New York, in September 1990, in conjunction with Prostate Cancer Awareness Week, a program of the Prostate Cancer Educational Council. Serum prostate specific antigen and digital rectal examination were used to screen 565 men. The two tests were equally effective in identifying patients with carcinoma. Of 118 patient...

In a 53-year-old male patient with metastatic adrenal carcinoma, treatment with mitotane was instituted but he was lost to follow-up. Two years later, he presented with oedema and nephrotic-range proteinuria. The rectal and renal biopsies revealed an accumulation of secondary amyloid material. The patient died of respiratory failure caused by the progressive pulmonary metastases. This is the fi...

the United States. A family history of colon cancer is a strong risk factor for development of the disease. Dietary factors have also been associated with the development of colorectal cancer. This article reviews the epidemiology, pathogenesis, genetics, clinical presentation, staging, and treatment of colorectal cancer. Surgical and adjuvant therapies for both colonic and rectal cancers are d...