Recent evidences associate thrombophilia with adverse pregnancy outcome. Numerous studies confirm Factor V Leiden (FVL) and Prothrombin G20210A (PT G20210A) mutations as important thrombophilia risk factors in Caucasians. However, these mutations are rare in Asians and thrombophilia investigations are therefore considered irrelevant in these patients. Hence, the status of thrombophilia-induced ...

Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Blighted ovum. The aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. Sixty Eight couples wit...

Early pregnancy loss in a wanted is stressful and frustrating to any couple. It becomes even more emotionally traumatic when it occurs repeatedly. Two or of early known as recurrent (RPL). RPL clinical challenge for physicians unriddle. In this case report, we illustrate 40-year-old woman who experienced six first-trimester losses. After the third loss, initial maternal blood investigations wer...

Background -Recurrent pregnancy loss defined as two or more miscarriage before 20 weeks of pregnancy affecting 1-5 % or women in reproductive age .There are many etiologies have been suggested, like Genetic, Immunologic, Thrombophila, Endocrine and Anatomic; but in 50% of cases, the exact etiology remains uncertain. Endometrium acts as biosensor of embryo quality and endometrium itself contribu...

Pregnancy is a significant event in a woman’s life, and emotional attachment to the pregnancy and developing baby may begin early in the first trimester. For most women, experiencing a first trimester loss is a difficult and vulnerable time. When it occurs, the grief can be as profound as for any perinatal or other major loss [1]. Spontaneous abortion (a pregnancy that ends spontaneously before...

BACKGROUND Determination of fetal aneuploidy is central to evaluation of recurrent pregnancy loss (RPL). However, obtaining this information at the time of a miscarriage is not always possible or may not have been ordered. Here we report on "rescue karyotyping", wherein DNA extracted from archived paraffin-embedded pregnancy loss tissue from a prior dilation and curettage (D&C) is evaluated by ...

Oxidative stress is worldwide recognized as a fundamental component of the aging, a process that begins before birth. There is a critical balance between free radical generation and antioxidant defenses. Oxidative stress is caused by an imbalance between the production of free radicals and the ability of antioxidant system to detoxify them. Oxidative stress can occur early in pregnancy and cont...

A large majority of pregnancy loss in cattle occurs during the first three weeks after conception, particularly during the peri-implantation period. This review integrates established and new information on the biological role of ovarian progesterone (P4), prostaglandins (PGs) and interferon tau (IFNT) in endometrial function and conceptus elongation during the peri-implantation period of pregn...

This review focuses on the possible role of T cells in successful pregnancy and in unexplained recurrent abortion. The functions exhibited by Th1 and Th2 cells have suggested, perhaps in a simplistic way, that Th1-type cytokines, which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines, by inhibiting Th1 responses, promote allograft tolerance and therefore may...

Some case-control studies have demonstrated that caffeine intake and high CYP1A2 activity increase risks of recurrent pregnancy loss (RPL) but the multifactorial effect is obscure. To investigate whether susceptible women who have more caffeine intake are at high risk of RPL, a case-control study of 58 cases with two or more RPL and fertile 147 controls was performed. The association between da...