The aim of this study was to explore the level of apoptosis and p53 expression in the placental villi of patients with unexplained recurrent spontaneous abortion (URSA). Fifty-three pregnant females with URSA and 32 pregnant females who required an induced abortion were selected as the subjects of this study. Placental villus tissues were collected from June 2010 to June 2012 and quantitative p...

One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46,...

OBJECTIVE Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. The adenosine deaminase G22A polymorphism (20q.11.33) influences the level of adenosine deaminase enzyme expression, which seems to play a key role in maintaining pregnancy. The adenosine deaminase 2 phenotype has been associated with a protective effect against recurrent spontaneous...

Background: Epidemiological evidence suggests that fine particulate air pollution, particularly particles less than 10 microns in diameter (PM10) exposure adversely affects pregnancy outcomes and usually aromatic hydrocarbons such as benzene bound to fine particles. We evaluated the impacts of PM10 and benzene on spontaneous abortion of first trimester of pregnancy in Tehran. Materials and Meth...

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...

Background Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood f...

Chronic (histiocytic) intervillositis (CHIV), defined for the purposes of this study as diffuse histiocytic infiltration of the intervillous space without villitis, is an idiopathic lesion seen in the chorionic sacs of some spontaneous abortion specimens and placentas. In this retrospective study, we evaluated all patients diagnosed with CHIV from 2 hospitals between 1993 and 2000, plus 1 addit...

PURPOSE To assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS In this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Co...

Received for publication: Apr. 06, 2007. Revised: Sep. 22, 2007. rEZUMat 1 Department of Medical Genetics, 2 Department of Obstetrics and Gynecology, Bega Clinic, Victor Babes University of Medicine and Pharmacy, Timisoara, 3 Department of Obstetrics and Gynecology, Vasile Goldis University, Arad

Background & Aims: It is believed that uterine septum, because of its effect on infertility and recurrent abortion is very important and pregnancy outcome is obviously improved by hysteroscopic metroplasty (HM). In this study, the probable relationship of uterine septum dimensions (length and width) with infertility and recurrent abortion has been investigated. Methods: This clinical trial was ...