1 (Oral/Poster) MULTICELLULAR HUMAN TESTICULAR ORGANOID: A NOVEL IN VITRO GERM CELL AND TESTICULAR TOXICITY MODEL Samuel Pendergraft, MS1, Hooman Sadri-Ardekani, MD, PhD2, Tanya Reid, BS3, Anthony Atala, MD2 and Colin Bishop, PhD1 1(1) Molecular Medicine and Translational Science Graduate Program, Wake Forest University Health Sciences, Winston-Salem, NC (2) Wake Forest Institute for Regenerati...

Regenerative medicine is a branch of this science that aims at providing strategies to restore the function of organs and/or tissues. It is a new form of therapy for patients with acute or chronic diseases in which the body is unable to restore tissue function. It is estimated that in the USA over 60million people could benefit from this type of treatment as it covers a broad range of clinical ...

Regenerative medicine for the cornea provides a novel treatment strategy for patients with corneal diseases instead of conventional keratoplasty. Limbal transplantation has been performed in patients with a limbal stem cell deficiency. This procedure requires long-term immunosuppression that involves high risks of serious eye and systemic complications, including infection, glaucoma, and liver ...

Mesenchymal stem/stromal cells (MSC) are currently the best candidate therapeutic cells for regenerative medicine related to osteoarticular, muscular, vascular and inflammatory diseases, although these cells remain heterogeneous and necessitate a better biological characterization. We and others recently described that MSC originate from two types of perivascular cells, namely pericytes and adv...

This chapter focuses on the latest developments in applications of carbonnanotubes (CNTs) for regenerative medicine. Regenerative Medicine focuses on technologies to create functional tissues to repair or replace tissues or organs lost due to trauma or disease. Carbon nonotubes (CNTs) have been under investigation in the past decade for an array of applications due to their unique and versatile...

Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological ...

The prevalence of blinding diseases such as agerelated macular degeneration (AMD), glaucoma and diabetic retinopathy have significantly increased in the United States over the last decade.1 In response to the higher incidence of retinal degenerative diseases, the National Eye Institute (NEI) of the US National Institutes of Health (NIH) has recently proposed the audacious goal of regenerating n...

Only ten years ago, 'stem cells' was a buzz word for all kinds of anticipated miracle cures, following the first production of human embryonic stem (ES) cell lines from blastocysts (early stage embryos) in 1998. As embryonic stem cells are pluripotent, they can generate the specialised cells for any kind of organ or tissue that one may want to create or repair, given the right enticement. While...