The pharmacokinetics of ciprofloxacin following single oral doses of 500 and 750 mg in 32 patients with various degrees of renal function impairment were investigated in an open, randomized crossover fashion. Ciprofloxacin was administered after overnight fasting; the washout time between the two doses was 1 week. Serum and urine samples were collected serially between 0 and 24 h and subjected ...

Introduction: Radical nephrectomy leads to decrease in global renal functions. Aim was to find histopathological factors in non tumor bearing renal parenchyma that can help in predicting the decline in global renal function. We would also study association of other factors like diabetes (DM) and hypertension (HTN) with decline in renal function and on non tumor parenchyma. Methods: Prospectivel...

BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (greater-than-or-equal 80) predicts progres...

OBJECTIVE: Diabetic nephropathy is a major diabetes complication. Arterial resistance index (RI) may predict deterioration in kidney function. This study was designed to compare renal arterial RI in different stages of renal function according to glomerular filtration rate (GFR), serum creatinine level and proteinuria. MATERIALS AND METHODS: In a cross-sectional study on 81 diabetic patients i...

Cramer, K., Goyer, R. A., Jagenburg, R., and Wilson, larion H. (1974). British Journal of Industrial Medicine, 31, 113-127. Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure. Renal biopsies were obtained from five men with heavy occupational exposure to lead and compared with studies of their renal function and parameters of...

background selenium deficiency is a common problem in patients with chronic kidney disease (ckd). this micronutrient has anti-inflammatory and anti-oxidant effects. selenium is also found in high concentrations in the thyroid gland. objectives to determine the effect of selenium supplementation on thyroid function tests and acute phase reactants in hemodialysis patients. patients and methods in...

BACKGROUND The importance of anaemia in chronic heart failure was highlighted recently by different cohort studies. The aim of this study was to assess the prevalence of anaemia and its relationship to renal function, left ventricular function and symptoms of heart failure. METHODS We surveyed cases of patients admitted to the Department of Cardiology during 22 consecutive months. Laboratory ...