Extensive research has been conducted to elucidate and substantiate the crucial role of Renin-Angiotensin System (RAS) in pathogenesis hypertension, cardiovascular disorders, renal diseases. Furthermore, oxidative stress maintaining vascular balance well established. It observed that many cellular effects induced by Angiotensin II (Ang II) are facilitated reactive oxygen species (ROS) produced ...

Gustavo Frindt and Lawrence G. Palmer 5 6 7 Dept. of Physiology and Biophysics 8 Weill-Cornell Medical College 9 New York, NY 10065 10 11 12 13 14 15 16 17 18 19 20 Address for correspondence: 21 Lawrence G. Palmer, Ph.D. 22 Dept. of Physiology and Biophysics 23 Weill-Cornell Medical College 24 1300 York Avenue 25 New York, NY 10065 26 27 28 Running title: Acute effects of aldosterone 29 30 Art...

Chronic hyperleptinemia results in the development of hypertension in pregnant rats 1 2 3 4 Ana C. Palei, Frank T. Spradley and Joey P. Granger 5 6 Department of Physiology and Biophysics and Cardiovascular-Renal Research Center, 7 University of Mississippi Medical Center – 2500 North State Street, Jackson/MS, 39216 8 9 10 11 Running head: Hyperleptinemia increases blood pressure in pregnant ra...

Labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. Biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. In other wor...

Transport at a price 13 14 15 16 17 Alan M. Weinstein, MD 18 Department of Physiology and Biophysics 19 Department of Medicine 20 Weill Medical College of Cornell University 21 22 23 24 25 26 27 Running title: Transport at a price 28 29 30 31 Address for correspondence and proofs: 32 Dr. Alan M. Weinstein 33 Department of Physiology and Biophysics 34 Weill Medical College of Cornell University ...

In cell culture, extracellular guanosine increases extracellular adenosine by attenuating the disposition of extracellular adenosine (American Journal of Physiology - Cell Physiology 304: C406-C421, 2013). The goal of this investigation was to determine whether this "guanosine-adenosine mechanism" is operative in an intact organ. Twenty-seven isolated, perfused mouse kidneys were subjected to m...

Endogenous NO is synthesized by nitric oxide synthases (NOS) which use L-arginine as substrate. The various isoforms of NOS are widely distributed within the kidney. Brain NOS (bNOS) and endothelial NOS (eNOS) are constitutively expressed and are both distributed in glomeruli and vasculature. In addition bNOS is found in epithelial tissue including macula densa and the collecting duct. Two stru...

Urine differs greatly in ion and solute composition from plasma and contains harmful and noxious substances that must be stored for hours and then eliminatedwhen it is socially convenient to do so. The urinary tract that handles this output is composed of a series of pressurizable muscular compartments separated by sphincteric structures. With neural input, these structures coordinate the deliv...

Multiphoton fluorescence microscopy offers the advantages of deep optical sectioning of living tissue with minimal phototoxicity and high optical resolution. More importantly, dynamic processes and multiple functions of an intact organ can be visualized in real time using noninvasive methods, and quantified. These studies aimed to extend existing methods of multiphoton fluorescence imaging to d...

cytoskeletal reorganization, morphogenesis, and cell migration (Figure 1). β 1 Pix also exhibits non-canonical activities in which it serves as a scaffolding protein in some signaling pathways (Pavlov et al., 2010). Staruschenko and Sorokin (2012) also provide an overview of the expression of βPix in the kidney and the various roles of βPix in kidney function. Recently, βPix expression has been...