Reactive oxygen species (ROS) play a key role in the acclimation process of plants to abiotic stress. They primarily function as signal transduction molecules that regulate different pathways during plant acclimation to stress, but are also toxic byproducts of stress metabolism. Because each subcellular compartment in plants contains its own set of ROS-producing and ROS-scavenging pathways, the...

OBJECTIVES Although azole antifungals are considered to be fungistatic, miconazole has fungicidal activity against planktonic Candida albicans cells, presumably associated with the induction of reactive oxygen species (ROS) production. Only few data are available concerning the effect of miconazole against sessile C. albicans cells. In the present study, the fungicidal activity of miconazole ag...

Background: Combination of glycation and oxidation is associated with diabetes mellitus. The aim of this study was to clarify the effect of glycated proteins in presence of transition metal ions on production of reactive oxygen species (ROS) in rat hepatocyte suspension.  Methods: Glycated albumin was prepared by incubation of bovine serum albumin with 100 mM glucose in 0.3 M phosphate buffer a...

In plants, receptor-like kinases (RLKs) and extracellular reactive oxygen species (ROS) contribute to the communication between the environment and the interior of the cell. Apoplastic ROS production is a frequent result of RLK signaling in a multitude of cellular processes; thus, by their nature, these two signaling components are inherently linked. However, it is as yet unclear how ROS signal...

Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to be the main cause of aging and age-related diseases including cancer, diabetes and Parkinson's disease. Accordingly, mitochondria from old individuals have higher levels of ROS. However, ROS also participate in cellular signaling, are instrumental for several physiological processes and boosting ROS levels in mod...

In plants, receptor-like kinases (RLKs) and extracellular reactive oxygen species (ROS) contribute to the communication between the environment and the interior of the cell. Apoplastic ROS production is a frequent result of RLK signaling in a multitude of cellular processes; thus, by their nature, these two signaling components are inherently linked. However, it is as yet unclear how ROS signal...

OVERPRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) in biological systems has been associated with the initiation or aggravation of diverse pathological states (14, 19). The presumed mechanism is through the ability of ROS to induce biochemical alterations in macromolecules such as DNA, lipids, and proteins (4, 14, 17). It has been known for some time that ROS, produced physiologically by leukocyte...

It is one of the paradoxes of biology that oxygen, which is required for energy production in aerobic organisms, is also very toxic. Many biological reactions generate reactive oxygen species (ROS) that strip electrons from biological molecules such as fatty acids, proteins and DNA. Exposure of cells to ROS can lead to disruptions in membrane structure, reduced activity of enzymes and other pro...

Reactive oxygen species (ROS) are widely involved in intracellular signaling and human pathologies, but their precise roles have been difficult to enumerate and integrate holistically. The context- and dose-dependent intracellular effects of ROS can lead to contradictory experimental results and confounded interpretations. For example, lower levels of ROS promote cell signaling and proliferatio...

Reactive oxygen species (ROS) were initially recognized as toxic by-products of aerobic metabolism, removed by means of antioxidants and antioxidative enzymes. In recent years, it has become apparent that ROS play an important signaling role in plants controlling processes such as growth, development, response to biotic and abiotic environmental stimuli, and programmed cell death. It is the evo...