Mohammad Taghi Goodarzi
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
[ 1 ] - Resveratrol attenuates visfatin and vaspin genes expression in adipose tissue of rats with type 2 diabetes
Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of st...
[ 2 ] - Adiponectin: an adipokine with protective features against metabolic syndrome
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
[ 3 ] - Study of Nonenzymatic Glycation of Transferrin and its Effect on Iron -Binding Antioxidant Capacity
Objective(s) Nonenzymatic glycosylation (glycation) occurs in many macromolecules in aging and diabetes due to exposure of biomolecules to high level of glucose. Glycation can changes function, activities and structure of many biomolecules. Considering this important role of transferrin (Trf) in iron transport and antioxidant activity in plasma this study was carried out to investigate the eff...
[ 4 ] - Glycation of Human IgG Induces Structural Alterations Leading to Changes in its Interaction with Anti-IgG
Background: Glycation of proteins is a non-enzymatic spontaneous process that occurs in diabetes mellitus and aging, altering the structure and function of proteins. IgG undergoes glycation leading to changes in its reactivity to antigen and fixation of complement. Objective: This study aimed at revealing the effect of glycation on the interaction of IgG with anti-IgG using electroimmunoassay...
[ 5 ] - بررسی ارتباط بین آدیپونکتین سرم با لیپپدهای خون و شاخص توده بدنی در زنان دیابتی نوع 2
زمینه: : آدیپونکتین که GBP-28، apM1، Adipo Q و Acrp30 نیز نامیده می شود، یک پروتئین اختصاصی مترشح از بافت چربی است که کاهش آن همراه با مقاومت به انسولین در تعدادی از مدل های حیوانی گزارش شده است. این مطالعه برای بررسی ارتباط بین آدیپونکتین با لیپیدهای خون و شاخص توده بدنی در زنان دیابتی و سالم انجام گردیده است. مواد و روش‌ها: میزان آدیپونکتین، LDL کلسترول، HDL کلسترول، تری گلیسیرید و کلسترول س...
[ 6 ] - مطالعه فاکتورهای التهابی در بیماران مبتلا به انسداد مزمن ریوی
Background & Aims : Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction. Many of the systemic manifestations of chronic obstructive pulmonary disease are mediated through increased systemic levels of inflammatory proteins. Oxidative stress and inflammation are the major hallmarks of COPD and inflammatory factors can be used as a biomarker to asses...
[ 7 ] - بررسی سطح سرمی آنزیم آدنوزین دآمیناز (ADA) در بیماران مبتلا به بیماری انسدادی مزمن ریه (COPD) و افراد سالم
چکیده زمینه و هدف: بیماری انسدادی مزمن ریه COPD (Chronic Obstructive Pulmonary Disease) بوسیله سازمان جهانی GOLD (Global Initiative For COPD) به عنوان بیماری تعریف شده است که با محدودیت جریان هوا مشخص می‌شود که بطور کامل برگشت‌پذیر نیست. COPD یکی از زیر مجموعه‌های بیماری‌های انسدادی ریه میباشد که فیبروز سیستیک، برونشیت و آسم را نیز در بر می‌گیرد. آنزیم ADA به شماره (E.C.3.5.4.4) باعث تبدیل آد...
[ 8 ] - آسیب اکسیداتیو DNA و لیپیدها و ارتباط آن با گلیکاسیون پروتئین در بیماران دیابتی نوع I
Background & Objective: Diabetic hyperglycemia is associated with increased production of Reactive Oxygen Species (ROS). ROS reacts with DNA results in products such as 8-hydroxydeoxyguanosine that excrete in urine due to DNA repair processes. This study aims to evaluate correlation between oxidative damage of DNA and protein glycation in patients with Type 1 diabetes. We measured urinary 8-O...
[ 9 ] - مطالعه سطح سرمی آدیپونکتین در زنان دیابتی نوع II و ارتباط آن با پروتئین واکنشگر C و هموگلوبین گلیکه شده
Introduction & Objective: Adiponectin secretes by adipose tissue and play an important role in hyperglycemia and inflammatory mechanism. The objective of this study was to compare the levels of adiponectin, CRP and HbA1c in diabetic and healthy women and to determine the correlation coefficient between these factors in each study group. Materials & Methods: We designed a case-control study...
[ 10 ] - Cytotoxic Effect of \" Glycated Albumin-Transition Metal Ion\" on Rat Hepatocyte Suspension
Background: Combination of glycation and oxidation is associated with diabetes mellitus. The aim of this study was to clarify the effect of glycated proteins in presence of transition metal ions on production of reactive oxygen species (ROS) in rat hepatocyte suspension. Methods: Glycated albumin was prepared by incubation of bovine serum albumin with 100 mM glucose in 0.3 M phosphate buffer a...
[ 11 ] - بررسی فیتوشیمیایی، آنتی‌اکسیدانی و اثرضد دیابتیک عصاره برگ‌های گیاه دارویی Trigonella foenumgraceum L. در منطقه همدان
گیاه دارویی شنبلیله (Trigonella foenumgraceum L.) علاوه بر مصارف فراوان غذایی، به‌دلیل سنتزترکیبات پلی‌فنلی دارای اثر آنتی‌اکسیدان و ضدالتهاب موثردر درمان دیابت است. این تحقیق در سال 1393 با هدف بررسی فیتوشیمیایی، آنتی‌اکسیدانی و ضددیابتی عصاره آبی برگ‌های شنبلیله انجام گرفت. برگ‌های گیاه از مزرعه گیاهان دارویی همدان تهیه و عصاره آبی آن با استفاده از روش خیساندن استخراج گرد...
[ 12 ] - Inhaled glucocorticoids promotes osteoporosis in asthma patients
Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects. Materials and Methods: To achieve this outcome, twenty one middle-aged asthma patients treated with inhaled cortico...
[ 13 ] - بررسی اثر سیلی مارین بر بیان ژن های اوروتنسین 2 و گیرنده آن در بافت کبد رتهای دیابتی تیپ 2
سابقه و هدف: مطالعات نشان میدهند که افزایش U-IIبا اختلالات دیابت مرتبط میباشد. با توجه به اینکه داروهای گیاهی برای درمان بیماری نسبت به بسیاری از داروهای شیمیایی عوارض کمتری دارند، در این مطالعه اثر سیلیمارین بر سطوح گلوکز، انسولین و بیان ژنهایU-II و گیرنده اوروتنسین2 (U-II R) در رتهای نر دیابتی تیپ2 مورد بررسی قرار گرفت. مواد و روش ها: در این مطالعه تجربی 36رت نر ویستار آلبینو به‌صورت ت...
[ 14 ] - Effects of Resveratrol on FOXO1 and FOXO3a Genes Expression in Adipose Tissue, Serum Insulin, Insulin Resistance and Serum SOD Activity in Type 2 Diabetic Rats
Induced oxidative stress in diabetes mellitus (DM) plays a critical role in insulin resistance. Fork head-related transcription factor (FOXO) proteins are important transcriptional factors involved in oxidative stress and insulin resistance. Resveratrol (RSV) is a polyphenol with hypoglycemic and antioxidant properties. The aims of the present study were to examine the effects of RSV on FOXO ge...
[ 15 ] - بررسی فیتوشیمیایی، آنتی‌اکسیدانی و اثرضد دیابتیک عصاره برگ‌های گیاه دارویی Trigonella foenumgraceum L. در منطقه همدان
گیاه دارویی شنبلیله (Trigonella foenumgraceum L.) علاوه بر مصارف فراوان غذایی، به‌دلیل سنتزترکیبات پلی‌فنلی دارای اثر آنتی‌اکسیدان و ضدالتهاب موثردر درمان دیابت است. این تحقیق در سال 1393 با هدف بررسی فیتوشیمیایی، آنتی‌اکسیدانی و ضددیابتی عصاره آبی برگ‌های شنبلیله انجام گرفت. برگ‌های گیاه از مزرعه گیاهان دارویی همدان تهیه و عصاره آبی آن با استفاده از روش خیساندن استخراج گرد...
[ 16 ] - Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats
Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...
[ 17 ] - Effects of Ascorbic Acid on Serum Level of Unconjugated Estriol and Its Relationship with Preterm Premature Rupture of Membrane: A Double-Blind Randomized Controlled Clinical Trial
Background: Vitamin C is a water-soluble antioxidant that not only stimulates and protects collagen synthesis but also plays an important role in maintaining cellular integrity in a normal pregnancy. This study surveyed the effects of ascorbic acid on the serum level of unconjugated estriol and the relationship between unconjugated estriol and preterm premature rupture of membrane (PPROM).Metho...
[ 18 ] - In Vitro Cytotoxic Effects of Cuscuta chinensis Whole Extract on Human Acute Lymphoblastic Leukemia Cell Line
Background: One of the major paths for drug development is the study of bioactivities of natural products. Therefore, the aim of this study was to compare the cytotoxic effects of aqueous extract of whole Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Iran and other oriental countries, on the human caucasian acute lymphoblastic leukemia (CCRF-CEM) and another hum...
[ 19 ] - Hepatoprotective Effects of Silymarin on Liver Injury via Irisin Upregulation and Oxidative Stress Reduction in Rats with Type 2 Diabetes
Background: Diabetes is one of the most prevalent metabolic diseases. Irisin (FNDC5 protein) is involved in the new strategy of combating type 2 diabetes. In the liver, the antidiabetic mechanism of silymarin at the molecular level is unknown. This study investigated the effects of silymarin on irisin and the related gene expression and oxidative stress status in the liver of type 2 diabetic ra...
[ 20 ] - Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects
The aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of Anethum graveolens (dill). In the in vivo and in vitro experiments, antioxidant properties, blood glucose, and AGEs formation were determined. Dill extract was given orally to healthy and diabetic rats. Our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, an...
[ 21 ] - The Effect of Biochanin A as PPAR γ agonist on LDL Particles Diameter and Type 2 Diabetic Dyslipidemia
Background and Aims: Small dense low-density lipoproteins (sd-LDL) particles are smaller and heavier than typical LDL ones. They can penetrate into the endothelium of coronary arteries more easily because of their small size. Diabetes mellitus is accompanied by dyslipidemia such as increasing concentration of plasma very low density lipoprotein and sd-LDL. Peroxisome proliferator activated rec...
[ 22 ] - comparison of serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin resistance rats with normal rats
Background and Purpose: Adipose tissue is not only a site of triglycerides storage, but also an active endocrine organ that secretes many biologically active mediators refered to as "adipokines". Visfatin, as a new adipokine has an important role in Homeostasis of energy and glucose metabolism. In the present study serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin re...
[ 23 ] - TLR2 and TLR4 Signaling Pathways and Gastric Cancer: Insights from Transcriptomics and Sample Validation
Background: Pattern recognition receptors, especially toll-like receptors (TLRs), as the first line of defense for pathogen detection, were found to be associated with H. pylori infection and gastric cancer (GC). However, the expression levels of TLRs, i.e. TLR2 and TLR4, as the main receptors sensed by H. pylori, still remain largely ambiguous. We aimed to investigate the patterns of key tra...
[ 24 ] - Single-nucleotide polymorphism of rs11061971 (+219 A>T) in adiponectin receptor 2 (AdipoR2) gene and its association with risk of type 2 diabetes among an Iranian population
Background and Objectives: Genetic modifications in the adiponectin receptor 2 (AdipoR2) gene can affect phenotypes associated with insulin resistance and diabetes. The purpose of this study was to evaluate the possible role of genetic modifications in the AdipoR2 gene, to determine the frequency of genotypes and polymorphism alleles of this gene at rs11061971 (+219 A>T), and to investigate its...
نویسندگان همکار