Azam Rezaei Farimani
Department of Clinical Biochemistry, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
[ 1 ] - Resveratrol attenuates visfatin and vaspin genes expression in adipose tissue of rats with type 2 diabetes
Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of st...
[ 2 ] - Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats
Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...
[ 3 ] - Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats
Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that type 2 diabetes could be caused by the modifications in the express...
[ 4 ] - Effect of Crocin and Losartan on Insulin Resistance and Protecting Pancreatic Tissue in Streptozotocin-Induced Diabetic Rats
Background and purpose: Crocin as a carotenoid exert anti-inflammatory, anti-oxidant, and anti-diabetic effects. There is an increasing prevalence of diabetes mellitus and its complications and patients are more interested in natural product treatments. This study aimed at investigating the efficacy of crocin and losartan alone and combination of the two drugs on insulin resistance and protecti...
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