BACKGROUND Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena. METHODOLOGY AND PRINCIPAL FINDINGS In transfected primary brain cultures, N-AChE-S induced cell death, morphological impair...

Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer's disease (AD)-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effect...

The greatest difficulty in diagnosing cognitive loss in our population is the diversity of its education which has a broad spectrum ranging from illiteracy, functional illiteracy and different degrees of literacy, even in those with the same level of schooling. Objectives To verify whether there is impairment on the S-TOFHLA among individuals with AD and MCI compared with healthy controls, an...

BACKGROUND Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown. METHODS We randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using...

The Internet of Things (IoT) framework is moving the research community to provide smart systems and solutions aimed at revolutionizing medical sciences healthcare. Given extreme diffusion Alzheimer’s disease (AD) Parkinson’s (PD), demand for a solution early detect neurological symptoms such diseases strongly arose. According literature, detection can be obtained through correlation betwee...

a case of sickle cell hb d disease is reported in  young iranian male. the father of whom carried an as sickle cell trait and the mother an ad trait. this disease was diagnosed by hb electrophoresis. agar gel electrophoresis sickling and solubility tests.this is the first case of sickle cell hb d disease reported in iran.

Alzheimer’s Disease (AD) is a neurodegenerative disorder that characterized clinically by progressive cognitive decline and pathologically the ?-sheet rich fibril plaque deposition of amyloid-? (A?) peptide in brain. While plaques are hallmark AD, burden not correlated with impairment. Instead, A? oligomers formed during aggregation process represent main agents neurotoxicity, which occurs 10–2...

introduction: although aging is the most important risk factor for alzheimer's disease (ad), there is evidence indicating that neuroinflammation may contribute to the development and progression of the disease. several studies indicated that minocycline may exert neuroprotective effects in rodent models of neurodegenerative diseases. nevertheless, there are also other studies implying that...

Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, developm...