In bacteria, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) DNA-targeting complex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bind complementary DNA targets at sites adjacent to a trinucleotide signature sequence called the protospacer adjacent motif (PAM). The Cascade complex then recruits Cas3, a nuclease...

in a subclass of the scale-parameter exponential family, we consider the sequential pointestimation of a function of the scale parameter under the loss function given as the sum of the weightedsquared error loss and a linear cost. for a fully sequential sampling scheme, second order expansions areobtained for the expected sample size as well as for the regret of the procedure. the former resear...

the problems of sequential change-point have several important applications in quality control, signal processing, and failure detection in industry and finance. we discuss a bayesian approach in the context of statistical process control: at an unknown time $tau$, the process behavior changes and the distribution of the data changes from p0 to p1. two cases are considered: (i) p0 and p1 are fu...

Department of Neurorehabilitation Sciences, Casa di Cura del Policlinico, Via Dezza 48, 20144 Milano, Italy. Electronic address: [email protected]. Department of Neurorehabilitation Sciences, Casa di Cura del Policlinico, Via Dezza 48, 20144 Milano, Italy. ISICO, Italian Scientific Spine Institute, Via Bellarmino 13/1, 20141, Milano, Italy. University of Brescia, Brescia, Italy; IRCCS Fond...

MD. Clinical geneticist, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) and Complexo Hospitalar Santa Casa de Porto Alegre (CHSCPA), Porto Alegre, Rio Grande do Sul, Brazil. MD. Assistant professor and Clinical Geneticist, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) and Complexo Hospitalar Santa Casa de Porto Alegre (CHSCPA), Porto Alegre, Rio Grande d...

Sequential ultrasound-microwave associated extraction (SUMAE) is a combination of ultrasound waves and microwaves energies in which ultrasonic extraction is used as a pretreatment. It was performed to extract essential oil from Zataria multiflora. The extraction conditions were optimized by response surface methodology (RSM) and Central Composite Design (CCD). The antioxidant and antibacterial ...

and forestry. To solve some of the problems in forestry and agriculture, the German Research Center for Artificial Intelligence and the Saarland Ministry of Economics founded the Cooperative Agents and Integrated Services for Logistic and Electronic Trading in Forestry and Agriculture (Casa) project. The Casa project focuses on developing an agentbased information and trading network (ITN). In ...

Flooding is one of the most common natural hazards that produce substantial loss of life and property. The QPE products that are derived at high spatiotemporal resolution, which is enabled by the deployment of a dense radar network, have the potential to improve the prediction of flash-flooding threats when coupled with hydrological models. The US National Science Foundation Engineering Researc...

spectrometric techniques for the analysis of trace lead have developed rapidly due to the increasing need for accurate measurements at extremely low levels of this element in diverse matrices. this review covers separation and preconcentration procedures, and considers the features of the application with several spectrometric techniques. the use of an appropriate sample handling technique is a...

Speech segregation, or the cocktail party problem, has proven to be extremely challenging. This presentation describes a computational auditory scene analysis (CASA) approach to the cocktail party problem. This approach performs auditory segmentation and grouping in a two-dimensional time-frequency representation that encodes proximity in frequency and time, periodicity, amplitude modulation, a...