BACKGROUND/AIMS We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. METHODS This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on...

HIV infection is a global disease that disproportionately burdens populations with nutritional vulnerabilities. Laboratory experiments have shown that selenium has an inhibitory effect on HIV in vitro through antioxidant effects of glutathione peroxidase and other selenoproteins. Numerous studies have reported low selenium status in HIV-infected individuals, and serum selenium concentration dec...

BACKGROUND High dietary intake of selenium or isoflavones reduces risk factors for prostate cancer. We tested whether combined supplementation of these two dietary components would reduce prostate cancer risk factors in rats more than supplementation of each component individually. METHODS Male Noble rat pups were exposed from conception to diets containing an adequate (0.33-0.45 mg/kg diet) ...

Introduction: The purpose of this study is to investigate the relationship of serum selenium levels and the risk of developing prostate cancer. It has been documented that antioxidants reduce the incidence of cancer by eradicating free radicals that damage DNA, thus increasing the risk of cancer. Selenium is a component of the antioxidant enzyme glutathione peroxidase, whose role in cancer prev...

The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear do...

The effect of combination of ginger and selenium on oxidative stress in rats was studied. Oxidative stress was induced in rats by single intraperiotoneal injection of potassium bromate (KBrO3) at a dose 125 mg/kg b.wt. Seven groups (n=7) of rats were used in this study. One of them was kept negative control and the others were given KBrO3. One was kept positive control and the others were given...

Background Several recent reviews, based mainly on observational studies, have however identified that micronutrient concentrations in the peri-conception period influence female fertility and embryogenesis, and may prevent adverse pregnancy outcomes.The possible effects on subfertility of two micronutrients(Zinc and Selenium), Components of antioxidant enzymes which are commonly included in or...

To establish guidelines for the selenium supplementation in radiotherapy we assessed the benefits and risks of selenium supplementation in radiotherapy. Clinical studies on the use of selenium in radiotherapy were searched in the PubMed electronic database in January 2013. Sixteen clinical studies were identified among the 167 articles selected in the initial search. Ten articles were observati...

BACKGROUND Dietary selenium is of fundamental importance to maintain optimal immune function and enhance immunity during infection. To this end, we examined the effect of selenium on macrophage bactericidal activities against Staphylococcus aureus. METHODS Assays were performed in golden Syrian hamsters and peritoneal macrophages cultured with S. aureus and different concentrations of seleniu...