Passive immunisation has been used in clinical practice since the end of last century, mainly for prophylaxis. Success of early treatments was marred by anaphylactic reactions and serum sickness because antibodies or antitoxins were not raised in humans. Recombination of gene segments during antibody synthesis means that specific antibodies for numerous antigens can be produced from a limited g...

background: little attention has been given to the relationship between work-life balance and sickness absence. objective: to investigate the association between poor work-life balance and sickness absence in 4 nordic welfare states. methods: multivariable logistic regression analysis was performed on pooled cross-sectional data of workers aged 15–65 years from denmark, finland, sweden, and nor...

BACKGROUND/OBJECTIVE Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in sepsis and cancer as well as in obesity. Here we report a pro-inflammatory role of visfatin in the brain, to mediate sickness responses including anorexia, hyperthermia and hypoactivity. METHODOLOGY Rats were...

BACKGROUND Mental disorders are common diagnostic causes for longer sickness absence and disability retirement in OECD-countries. Short sickness absence spells are also common, and neither trivial for health and work ability. We studied how prior short sickness absence spells and days are associated with subsequent longer sickness absence due to mental disorders in two age-groups of municipal e...

A pilot study was carried out on the detection of trypanosome-specific antibodies in saliva for diagnosis of sleeping sickness. All twenty-three saliva samples of parasitologically confirmed Trypanosoma brucei gambiense patients tested positive in an indirect enzyme-linked immunosorbent assay, whereas all 14 saliva samples of a negative control group remained negative. Trypanosome-specific anti...

We established inducible osteonecrosis in a rabbit serum sickness model. Osteonecrosis with marrow necrosis could be induced by the intravenous injection of horse serum in two doses separated in time by a period of three weeks. In this model, osteonecrosis could be successfully produced in rabbit femoral metaphysis. The incidence of marrow necrosis was 45% (9 of 20 rabbits) and trabecular necro...

Chronic serum sickness leads to the formation of glomerular immune complexes; however, C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CFH) is absent from the plasma. Here we studied the role for C5a receptor (R) in this setting. The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR(-/-) double knockout mice, highlighting the C5aR dep...

AIM To compare levels of self-efficacy among the general working population and employees with sickness absence from work, and to examine if general self-efficacy measured before occurrence of sickness absence predicted subsequent onset of sickness absence and Return-to-Work. METHODS The study follows a cohort of 5357 working employees and 106 long-term sickness absent employees in Denmark. T...

FACULTY OF ENGINEERING AND APPLIED SCIENCE INSTITUTE OF SOUND AND VIBRATION RESEARCH Doctor of Philosophy VISUAL ACUITY, EYE MOVEMENTS, THE ILLUSION OF MOTION AND MOTION SICKNESS WITH OPTOKINETIC STIMULI by Nicholas Andrew Webb Motion sickness and the illusion of self-motion (vection) can be induced by the use of an optokinetic drum (a black and white striped cylinder which rotates around a sea...