polyclonal anti-thymocyte globulin (atg) is used as an immunosuppressive agent in the treatment of aplastic anemia (aa). serum sickness is a recognized side effect of atg. we observed abnormal skin manifestation in patient with aplastic anemia who had been treated with atg. we conclude that abnormal immune function caused by aplastic anemia and atg and corticosteroids may aggravate the signs of...

Serum sickness is an immune-complex-mediated systemic illness that can occur after treatment with monoclonal or polyclonal antibodies such as Rituxan (Rituximab) or antithymocyte globulin (Thymoglobulin), respectively. Since Rituximab is now being used as an adjuvant treatment for acute humoral rejection and its prevalence to cause serum sickness is comparable to Thymoglobulin-associated serum ...

Serum sickness is a type III hypersensitivity reaction that occurs due to the deposition of excessive circulating immune complexes in patients treated with foreign proteins or haptens. Serum sickness induced by antivenin for snakebites has been frequently reported in the USA, but not in Taiwan. This difference may be due to the efficacy and dosage of antivenins administered to treat snakebites ...

Serum sickness is immune response to a foreign antigen, usually a heterologous protein. Incidence rate is less than 0.5%. Antigens and responding antibodies form circulating immunocomplex that is characteristic for serum sickness. The condition occurs 7-15 days after exposure to the antigen, usually with clinical picture of glomerulonephritis. The immunocomplex circulates to other tissues where...

The occurrence in man of reactions subsequent to a first injection of certain foreign proteins has long been recognized and, following the general use of antisera of various types, these reactions were thoroughly studied by von Pirquet and Schick (1) who gave the name serum sickness or serum disease to this phenomenon. I t was possible to study it quite extensively as it occurs in man. However,...

CONTEXT Serum sickness is a delayed immune reaction resulting from the injection of foreign protein or serum. Antivenom is known to cause serum sickness but the incidence and characteristics are poorly defined. OBJECTIVE To investigate the incidence and clinical features of serum sickness following the administration of Australian snake antivenoms. MATERIALS AND METHODS This was a prospecti...