نتایج جستجو برای: signaling pathway
تعداد نتایج: 522744 فیلتر نتایج به سال:
Background and purpose: Interest into targeting PI3K in cancer has increased by the recent disclosure that aberrant activity of PI3K/Akt signaling pathway is associated with disease recurrence and poor outcome in different malignancies. The aim of this study was to investigate the potentiating effect of PI3K inhibitor, GS-1101 on doxorubicin-induced cell death in acute lymphoblastic leukemia-de...
Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. loss of protein associates tumor metastasis and poor survival GC patients. During progression, an aberrantly elevated miR-20a-5p expression has been found, which induces phosphorylation, t...
Interleukin-11 (IL-11) is a pleiotropic cytokine with both pro- and anti-inflammatory properties. It activates its target cells via binding to the membrane-bound IL-11 receptor (IL-11R), which then recruits homodimer of ubiquitously expressed, signal-transducing gp130. Besides this classic signaling pathway, can also bind soluble forms IL-11R (sIL-11R), IL-11/sIL-11R complexes activate inductio...
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