Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human neuroblastoma cells to protease activity derived from botulinum neurotoxin type C. We show that following retinoic acid treatment, human neuro...

The Computer-Aided Manufacturing Engineering (CAME) program is developing a number of integrated software toolkits for design, manufacturing engineering, and production operations [1]. One of these toolkits is the Manufacturing Engineering ToolKit (METK) [2]. The goals of the METK project are 1) to develop generic interface specifications, data structures, information models, and data validatio...

We report new paleomagnetic data for the Middle Pleistocene hominid-bearing strata in the Sima de los Huesos, North Spain. Sediments (brown muds with human and bear fossils and the underlying sterile clayey and sandy unit) preserve both normal and reversed magnetic components. The sterile unit has exclusively reversed magnetization, dating back to the Matuyama Chron, and thus is Lower Pleistoce...

An autonomous agent must know where it is, which objects are in the nearby surrounding area and where it can find already seen, far away objects. On the basis of the existing cognitive architecture Simulation of Mental Apparatus and Applications (SiMA) at the Institute of Computer Technology (ICT) we show, how cognitive architectures can get extended by location awareness and navigation. This p...

This study describes and compares two hyoid bones from the middle Pleistocene site of the Sima de los Huesos in the Sierra de Atapuerca (Spain). The Atapuerca SH hyoids are humanlike in both their morphology and dimensions, and they clearly differ from the hyoid bones of chimpanzees and Australopithecus afarensis. Their comparison with the Neandertal specimens Kebara 2 and SDR-034 makes it poss...