background & objective: streptococcosis is one of the bacterial infections in fish, especially rainbow trout which infects brain and nervous systems of fish and is caused by s. iniae . estimation of the impact of disease prevalence by s. iniae in fish farming in some countries is reported about 100 million dollars per year. some of the most effective proteins in pathogenicity of these bacteria ...

The Drosophila melanogaster (Dm) similar (sima) gene was isolated using a low-stringency hybridization screen employing a Dm single-minded gene basic helix-loop-helix (bHLH) DNA probe. sima is a member of the bHLH-PAS gene family and the conceptual protein shares a number of structural features, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches. Sima is most closely re...

BACKGROUND Streptococcus iniae is a significant pathogen in finfish aquaculture, though knowledge of virulence determinants is lacking. Through pyrosequencing of the S. iniae genome we have identified two gene homologues to classical surface-anchored streptococcal virulence factors: M-like protein (simA) and C5a peptidase (scpI). METHODOLOGY/PRINCIPAL FINDINGS S. iniae possesses a Mga-like lo...

Fungi are adept at occupying specific environmental niches and often exploit numerous secondary metabolites generated by the cytochrome P450 (CYP) monoxygenases. This report describes the characterization of a yeast-specific CYP encoded by simA ("survival in macrophages"). Deletion of simA does not affect yeast growth at 37°C in vitro but is essential for yeast cell production during macrophage...

Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF-a polypeptides, thereby promoting their proteasomal degradation. So far, however, the developmental consequences of the inactivation of PHDs in higher metazoans hav...

Even though the high-temperature formability of Al alloys can be enhanced by the strain-induced melt activation (SIMA) process, the mechanical properties of the formed alloys are necessary for estimation. In this research, a modified two-step SIMA (TS-SIMA) process that omits the cold working step of the traditional SIMA process is adopted for the 6066 Al-Mg-Si alloy to obtain globular grains w...

Simvastatin (SIM)-induced myopathy is a dose-dependent adverse drug reaction (ADR) that has been reported to occur in 18.2% of patients receiving a 40- to 80-mg dose. The pharmacokinetics of SIM hydroxy acid (SIMA), the bioactive form of SIM, and the occurrence of SIM-induced myopathy are linked to the function of the organic anion transporting polypeptide (Oatp) hepatic uptake transporters. Ge...

This paper describes the hardware implementation of Simple Integrated Media Access (SIMA) access node. SIMA introduces Quality of Service (QoS) in IP networks by using the IPv4 Type of Service (TOS) field as priority and real-time indication field. Hardware acceleration is used to speed up the SIMA cal-culations.

The Drosophila melanogaster gene archipelago (ago) encodes the F-box/WD-repeat protein substrate specificity factor for an SCF (Skp/Cullin/F-box)-type polyubiquitin ligase that inhibits tumor-like growth by targeting proteins for degradation by the proteasome. The Ago protein is expressed widely in the fly embryo and larva and promotes degradation of pro-proliferative proteins in mitotically ac...

The basic objectives of future Internet are to increase the network capacity, to offer a practical real-time service, and to develop a feasible charging scheme. These objectives introduce very strict requirements for the trafilc control system. This paper presents a new simple approach for traffic management: Simple Integrated Media Access (SIMA). According to the SIMA concept each customer sha...