The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pa...

Sox genes encode proteins related to each other, and to the sex determining gene Sry, by the presence of a DNA binding motif known as the HMG domain. Although HMG domains can bind to related DNA sequences, Sox gene products may achieve target gene specificity by binding to preferred target sequences or by interacting with specific partner proteins. To assess their functional similarities, we re...

TCF and SOX proteins belong to the high mobility group box transcription factor family. Whereas TCFs, the transcriptional effectors of the Wnt pathway, have been widely implicated in the development, homeostasis and disease of the intestine epithelium, little is known about the function of the SOX proteins in this tissue. Here, we identified SOX9 in a SOX expression screening in the mouse fetal...

everal sections of the Sarbanes– Oxley Act of 2002 (SOX) directly affect the governance of the information technology (IT) organization, including potential SOX certification by the chief information officer, Section 404 internal control assessments, “rapid and current” disclosures to the public of material changes, and authentic and immutable record retention. The Securities and Exchange Commi...

This paper investigates the effects of the Sarbanes-Oxley Act (SOX) on CEO compensation, using panel data constructed for the S&P 1500 firms on CEO compensation, financial returns, and reported accounting income. Empirically SOX (i) changes the relationship between a firm’s abnormal returns and CEO compensation, (ii) changes the underlying distribution of abnormal returns, and (iii) significant...

In 2002, the Sarbanes-Oxley Act was passed into law requiring all U.S. based, publicly traded companies to report on the status of their internal controls governing the reporting of financial information. Because of the close relationship between financial reporting and IT, the requirements of the Sarbanes-Oxley (SOX) Act has also greatly impacted IT Governance and the way IT projects are manag...