Sirosis hepatis adalah tahap akhir penyakit hati dengan berbagai penyebab, antara lain kelainan metabolik atau infeksi hepatitis B dan C. Hingga saat ini, sirosis diyakini sebagai proses tidak reversibel, yang berujung transplantasi hati. Namun, seiring perkembangan teknologi pemahaman tentang patogenesis, mungkin bersifat reversibel.
 Liver cirrhosis is a final stage of liver disease with...

BACKGROUND Cirrhosis liver claims many lives in our country. However early diagnosis carries good prognosis and prevents complications. Estimation of serum sialic acid level may be helpful in the diagnosis of liver cirrhosis and following the dynamics of the disease especially during treatment and follow up to see the prognosis. METHODS Sialic acid level of 82 confirmed liver cirrhosis patien...

Background: Progressive fibrosis and cirrhosis, clinically presenting as end-stage liver disease are common outcomes in alcoholic hepatitis as well as non-alcoholic fatty liver disease(NAFLD). In these processes, a series of changes occurs in liver tissues leading to cell death, remodeling, fibrosis and regeneration. The aim of this study is to identify potential novel biomarkers for non-invasi...

The liver organ allocation policy of the United Network for Organ Sharing (UNOS) is based on the model for end-stage liver disease (MELD). The policy provides additional priority for candidates with hepatocellular carcinoma (HCC) who are awaiting deceased donor liver transplantation (DDLT). However, this priority was reduced on February 27, 2003 to a MELD of 20 for stage T1 and of 24 for stage ...

The aim of this study was to evaluate and compare the Child-Turcotte-Pugh (CTP) classification system and the model for end-stage liver disease (MELD) score in predicting the severity of the systemic inflammatory response in living-donor liver transplantation patients. Recipients of liver graft were allocated to a recipient group (n = 39) and healthy donors to a donor group (n = 42). The associ...

UNLABELLED Candidates with fulminant hepatic failure (Status-1A) receive the highest priority for liver transplantation (LT) in the United States. However, no studies have compared wait-list mortality risk among end-stage liver disease (ESLD) candidates with high Model for End-Stage Liver Disease (MELD) scores to those listed as Status-1A. We aimed to determine if there are MELD scores for ESLD...

Until recently, the major causes of end-stage liver disease in Korea were chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infections and alcoholic liver disease. However, hepatitis B vaccinations and antiviral drugs are anticipated to significantly reduce end-stage liver disease caused by hepatitis viruses. In contrast, the incidence of obesity-related metabolic syndrome has...

We report the clinical and morphological features of an unusual hepatorenal disorder in 2 patients. The main clinical features were early onset of cholestatic liver disease and progressive tubulointerstitial nephritis, leading to renal death in early childhood. Renal histology showed interstitial fibrosis, tubular atrophy and dilatation, glomerular cysts in the cortex and periglomerular fibrosi...

We report the clinical and morphological features of an unusual hepatorenal disorder in 2 patients. The main clinical features were early onset of cholestatic liver disease and progressive tubulointerstitial nephritis, leading to renal death in early childhood. Renal histology showed interstitial fibrosis, tubular atrophy and dilatation, glomerular cysts in the cortex and periglomerular fibrosi...