o-Benzenedisulfonimide (OBS) has efficiently catalysed the one-pot three-component reaction of ketones and aromatic amines with trimethylsilyl cyanide (TMSCN) giving the corresponding α-amino nitriles in excellent yields (23 examples; average yield 85%). Reaction conditions were very simple, green and efficient. Theoretical calculations have allowed us to explain the mechanism of this reaction ...

Gordon Bell, William Il. Strecker November 8, 1975 COMPUTER STRUCTURES: WHAT HAVE WE LEARNED FROM THE PDP-ll? Over the FDP-11’S six year life about 20,000 specimens have been built based on 10 species (models). Al though range was a design goal, it was unquantified; the actual range has exceeded expectations (5OO:l in memory size and system price]. The range has stressed the baa ic mini (mall c...

This booklet consists of the addresses delivered at the opening of the new laboratory for biochemical research at McLean Hospital. Cecil K. Drinker reviews the history of research at McLean Hospital. Jordi Foich surveys biochemical research in psychiatry with emphasis on his own contributions to the chemical constitution of the brain. The record of reasearch at the Psychiatric Service of the Ma...

Pregnancy and the post-partum period are generally regarded as maturational crises equal in importance to those of adolescence and the menopause. Stresses undergone during this period include (a) endocrine changes, (b) activation of unconscious psychological conflicts pertaining to pregnancy and (c) the intrapsychic reorganization ofbecorning a mother. In light of this, it seems likely that cli...

The fermentation of carbohydrates by Bacillus macerans yields ethanol, acetone, acetic and formic acids, hydrogen, and carbon dioxide (Schardinger, 1905; Donker, 1926). In bacteria, hydrogen is known to arise anaerobically through pyruvate cleavage which also yields acetate and CO2. The most thoroughly studied of these reactions are the phosphate-requiring cleavage reactions in Escherichia coli...