In their article in the current issue of Clinical Chemistry, Farrell et al. (1 ) describe the latest in a number of studies (2, 3 ) highlighting the method-related variability in serum 25-hydroxyvitamin D (25-OHD) results. There is common agreement that 25-OHD is a “difficult” analyte. That quality is generally ascribed to its hydrophobic nature, its existence in several different molecular for...

We evaluated two multi-analyte analyzers, the NOVA Stat Profile 1 (SP 1) and the NOVA Stat Profile 5 (SP 5). The SP 1 measures pH, pCO2, pO2, sodium, potassium, ionized calcium, and hematocrit in heparinized whole blood; the SP 5 determines all these analytes, plus chloride (not evaluated because it was unavailable at the time this study was initiated) and glucose. Interassay precision for pH, ...

INTRODUCTION Nanoscaled aptamers (Aps), as short single-stranded DNA or RNA oligonucleotides, are able to bind to their specific targets with high affinity, upon which they are considered as powerful diagnostic and analytical sensing tools (the so-called "aptasensors"). Aptamers are selected from a random pool of oligonucleotides through a procedure known as "systematic evolution of ligands by ...

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a bstract   background: there are a few studies about commissioning mothers’ understanding from the surrogacy during 9 months of waiting for delivery in iran and other countries. this study was conducted with an aim to explore and explain the nature of concerns (experiences) of commissioning mothers. materials and methods:  a qualitative design with a conventional content analysis approach was ...

Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the risk of cerebrovascular accident (CVA). LA patients need preventive medication for CVA. IMT is a non-invasive diagnostic and prognostic test in LA. The aim of this study was evalua...

In this work we present an electrochemical microfluidic platform for the detection of multiple analytes. The developed system allows the simultaneous readout of up to four different enzyme-linked assays even in various formats. The applicability was shown with the antibiotic detection of tetracycline in different concentrations by means of a DNA-based assay on a single chip. With a sample-to-re...

point of care (POC) in critical care areas such as the emergency department, neonatal and adult medical intensive care units, surgical intensive care units, and the operating room.2 The collection and analysis by portable or standard blood gas machines at or near the point of care minimizes the time needed to obtain and report laboratory values, which facilitates timely evaluation of results an...

in surrogate pregnancies genetic parents have little opportunity for early bonding with their infants either prenatally (in utero) or during the immediate postnatal period. procedures commonly used to induce lactation include both pharmacologic and nonpharmacologic methods often in combination. studies reporting induced lactation are sparse due to the rarity of augmented lactation. here we repo...

A liquid chromatographic (LC) method for the analysis of sulfamethazine (SMT) in complete swine and cattle feed was collaboratively studied. The method uses post-column derivatization with dimethylaminobenzaldehyde and detection at 450 nm. To 5g finely ground feed, extractant (0.2N HCl + 1.5% diethylamine in 25% methanol), and internal standard solutions are added, and the SMT is extracted by s...