dibutyl phthalate (dbp) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. dbp is found in almost every plastic material and is believed to be persistent in the environment. various analytical methods have been used to measure dbp in different matrices. considering the ubiquitous nature of dbp, the most important challenge in dbp analyses is the contam...

Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...

Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...

Chromatographic methods are increasingly being used for the quantitative determination of endogenous compounds in biological samples. This article presents an overview of the specific issues, which have to be taken into account for the development, validation and application of these methods. The usual lack of analyte-free samples of the biological matrix implies that alternative strategies for...

State-of-the-art prospective quality-control systems entail the use of medically relevant, analyte-specific quality control limits. With analyte-specific limits broader than those generally used in the clinical laboratory, there will be fewer false rejections, fewer unnecessary reanalyses, and shorter delays in run reporting. If the analyte-specific limits are narrower than those used in the la...

BACKGROUND Quantitative immunohistochemical (IHC) assays currently lack optimal reference quality-control material for cellular protein targets. To address this problem, we identified peptides that mimic the site on the native analyte to which the primary (monoclonal) antibody binds and used them as surrogate peptide controls. METHODS We identified peptide candidates from a combinatorial pept...

Endogenous steroid hormones and endocannabinoids (ECs) are important regulators in the stress response of human body. For measurement chronic stress, hair analysis has been established as method choice for long-term retrospective determination endogenous markers. A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification five (cortisone, cortisol, androstenedione, test...

Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...

Perfluorinated compounds are ubiquitous in the environment and have been reported to occur in human blood. Accurate risk assessments require accurate measurements of exposures, but identification and quantification of PFCs in biological matrices can be affected by both ion suppression and enhancement in liquid chromatography-tandem mass spectrometry techniques (LC/MS-MS). A study was conducted ...

An analytical method is required for the analysis of monoterpenes in animal plasma to support a pharmacokinetic study. Monoterpenes common to sagebrush are extracted from sheep plasma by employing solid-phase extraction (SPE), followed by analysis of the extracts by gas chromatography with flame ionization detection. The analytes are quantitated versus an external standard and by comparison wit...